RESPON IMUN PADA FETUS

DENGAN KEHAMILAN
TOXOPLASMOSIS
Life Cycle of Toxoplasma Gondii
How Human Can be Infected
 Encapsulation of zygote
Cats Ingest of asexual stage Zygote within a rigid wall
tachyzoites & bradyzoites

Oocyst
Gametocytes

Multiplication

Bradyzoites infect Merozoites

cells and become
trophozoites.
Cat’s intestinal enterocytes
WHAT IS CONGENTIAL TOXOPLASMOSIS
■ When a pregnant woman gets the infection during
pregnancy and passes it on to her fetus.

■ Women who get toxoplasmosis before conception

hardly ever pass the infection during pregnancy.

■ Babies that get infected during the first trimester

show to have the most severe symptoms.
Fetal Immune Response Toxoplasmosis
 Congenital Toxoplasmosis

1. Intracerebral calcification. toxoplasmic encephalitis

2. Chorioretinitis . Ocular toxoplasmosis
3. Hydrocephaly.
Congenital disease
4. Microcephaly .
5. Convulsions.
6. Mental retardation .
7. Cardiomegaly .
 Effects of Ocular Toxoplasmosis

Common Effects: Occasional Effects:

– Inflammation of retina – Cataracts

– Blurred vision – The eye can be small
– Floaters – Optic atrophy
– Nystagmus – Cerebral visual impairment
– Amblyopia
– Squint
HYDROCEPHALUS
CONGENITAL
TOXSOPLAMOSIS
Congenital toxoplasmosis is a problem in 1-5/1000 pregnancies

* Intracerebral calcification.
■ If a woman is infected for the first
time during pregnancy the
parasite can cross the placenta
and cause fetal disease.
■ Both the* probability and severity
of the disease depend on when
the infection takes place during
pregnancy.
■ Early: low transmission, but
severe disease
■ Late: high transmission, more
benign symptoms.
 Hydrocephaly.