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MERCK Workshop Intrauterine Insemination 2018 Bengkulu
MERCK Workshop Intrauterine Insemination 2018 Bengkulu
FSH Cycle control Ovulation Oocyte & Fertilization Embryo growth, Embryo Embryo transfer Luteal phase
stimulation triggering sperm management & preservation support
preservation assessment
Geri: Incubator
Gonal-f : FSH Recombinant Cetrotide : Gnrh Antagonist Gavi : Automatic Vitrification
Pergoveris : FSH Recombinant + LH Recombinant Crinone : Progesterone Gel Gems: Media culture
Ovidrel : HCG Recombinant
Gidget : IVF Witness
2 Workshop IUI Regional Obgin Sumbangsel ( Rosade 2018)-HPS
OI-IVF Drugs Treatment
Gnrh Antagonist/Cetrorelix
Recombinant HCG
Progesterone Gel
ER Translation Maturation
Secretion
Expression
vector Mature hFSH
molecule
HCG IIU
USG USG USG USG
FSH FSH FSH FSH FSH FSH FSH
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
KS KS KS KS KS
1. Diberikan klomifen sitrat 100 mg per hari pada hari ke-2 sampai 6 siklus haid
2. FSH 75-100 IU mulai diberikan pada hari ke-6 sampai didapatkan perkembangan
folikel yang sesuai target
3. Bila didapatkan hasil seperti di atas,hCG diberikan dengan dosis 250 mcg.
4. Coitus 24-48 Jam Kemudian atau
5. IIU Dilakukan Jika Ada Gangguan Sperma Ringan
HCG IIU
USG USG USG USG
FSH FSH FSH
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
KS KS KS KS KS
1. Diberikan klomifen sitrat 100 mg per hari pada hari ke-2 sampai 6 siklus haid
2. FSH 75-100 IU mulai diberikan selang seling sampai didapatkan perkembangan folikel
yang sesuai target
3. Bila didapatkan hasil seperti di atas,hCG diberikan dengan dosis 250 mcg.
4. Coitus 24-48 Jam Kemudian atau
5. IIU Dilakukan Jika Ada Gangguan Sperma Ringan
8 Ovulation
Workshop IUI Regional Obgin Sumbangsel ( Rosade 2018)-HPS
19 GDM
GDM Fertility
Fertility Plan –2014
Plan 2014 Final–Draft
Final Draft
Under UnderbyReview
Review Induction
by Legal Department
Legal Department
Efikasi , Keamanan, Efisiensi Gonal-f ?
P 0.008
20 17.4
15
10
0
Clinical Pregnancies ( per cycle) (%)
Low Dose Rec FSH CC
Group A : Gonadotropin
Group B : CC + Gonadotropin
Group A : Gonadotropin
Group B : CC +Gonadotropin
GONAL-f reduces teaching time GONAL-f decreases institutional GONAL-f decreases the per-cycle
manpower cost patient cost
40 1200
4.00
1000 80%
30 76% 800 3.00
YEN
YEN
3.20
20 600
2.00
400
10 1.00
11.4 200 303.6
0 0.00
0 GONAL-f RFF u-FSH HP-hMG GONAL-f RFF u-FSH HP-hMG
GONAL-f RFF GONAL-f PEN AMPOULE AMPOULE PEN AMPOULE AMPOULE
PEN AMPOULE FOR
SELF-INJECTION
Serum gonadotrophins
and
serum E2 levels
OI OI OI?
IVF IVF IVF?
egg donation
E2, oestradiol; FSH, follicle-stimulating hormone; IVF, in vitro fertilization; LH, luteinizing hormone; OI,
ovulation induction; PCOS, polycystic ovary syndrome
Insler &Workshop
21
Lunenfeld. New York: Churchill Livingston, 1972; WHO. Cambridge, Cambridge University Press,
IUI Regional Obgin Sumbangsel ( Rosade 2018)-HPS
+ 75 IU
+ 75 IU
+ 75 IU
Pergoveris +
Pergoveris + Gonalo-f (FSH)
Pergoveris + Gonal-f (FSH 225 IU
Pergoveris 1 box (FSH 150/LH 75 ) Gonal-f (FSH ) )150 IU
75 IU
1 7 14 21 28
Protocol Konvensional
Mulai kapan saja dengan Pergoveris 1 box ( FSH 150 IU / LH 75 IU)
Dosis ditingkatkan sesudah 7 hari dengan Gonal-f (FSH) 75 IU
jika tidak ada bukti pertumbuhan folikel pada U/S
Suntikkan r-hCG 250g saat 1 folikel dominant >= 17/18mm &
22 tidak
Workshop IUI Regional lebih
Obgin dari
Sumbangsel 3 folikel
( Rosade 2018)-HPS >=16mm
PEMICU OVULASI UNTUK OI-IUI
Multiple Pregnancies 0 1
Progressive diffusion of progesterone from the cervix to the fundus of the uterus
Dose
delivered
Fill Level
1.125 (1.45 g (C) / 2.6 g
g (B))
58.7
60
50
44.3
40
32.04
30
23.89
20
10
0
Pregnancy Rate Implantation Rate
Progesterone Gel ( Crinone) Capsul Progesterone ( Uterogest)
39
Workshop IUI Regional Obgin Sumbangsel ( Rosade 2018)-HPS
Crinone Vs Progesterone tablet intra vaginal
Rute pemberian Intra vagina Intra vagina, rectal Oral, Intra vagina,
Cara penggunaan Aplikator ke intra Jari tangan ke dalam Jari tangan ke dlm
Vagina vagina vagina
Tidak Meluber Meleleh Dan Meluber
43
Women Health Product
Hemobion
AZOL
Cavit D3
CAVIT D3
HEMOBION
AZOL
46 Workshop IUI Regional Obgin Sumbangsel ( Rosade 2018)-HPS