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2016 Neural Crest Cells
2016 Neural Crest Cells
2016 Neural Crest Cells
•Melanocytes
NCC leave the crests area of the neural folds prior to neural tube closure
and migrate to form structures in the neck and face, pharangeal arches (1-6)
Epibranchial placodes (V,VII, IX and X)
Cranial NCC from rhombomere regions
induce
induce
2nd wave of transcription factors:
SNAIL and FOXD3 which specify cells as neural crest
SLUG which promotes NCC migration from neuroectoderm
How is migration initiated?
ECM proteins
2) Endothelin-3
NCC melanocytes
NCC adrenergic neurons in the gut
3) Glucocorticoids : NCC adrenomedullary cells
4) FGF : NCC sympathetic neurons
What specify the fates of NCC?
Hox genes are a particular subfamily of homeobox containing genes that evolved
together with a complex multicellular body plan.
They have been utilised to convey positional information and organise the body
plan