Professional Documents
Culture Documents
Pleu Effusion
Pleu Effusion
Overview of
of pleural
pleural effusion
effusion in
in adults
adults
UPUL PATHIRANA
12/13/2014 1
12/13/2014 2
Mechanisms
Mechanisms of
of pleural
pleural liquid
liquid accumulation
accumulation in
in disease
disease
DECREASED
FLUID EXIT
an abnormal
accumulation of
fluid in the pleural
space.
INCREASED
FLUID ENTRY Pleural effusion
6/2/2011 3
Making the diagnosis
12/13/2014 4
Conventional
Conventional radiography
radiography
12/13/2014 5
Conventional
Conventional radiography
radiography
12/13/2014 6
Conventional
Conventional radiography
radiography
12/13/2014 7
Conventional
Conventional radiography
radiography
“meniscoid arc ‘’
12/13/2014 8
Conventional
Conventional radiography
radiography
12/13/2014 9
Conventional
Conventional radiography
radiography
“pseudotumors or vanishing
tumors”
12/13/2014 10
Conventional
Conventional radiography
radiography
12/13/2014 11
Ultrasonography
Ultrasonography
AnechoicNormal
area (transudative
appearance effusion)
12/13/2014 12
Ultrasonography
Ultrasonography
12/13/2014 13
Computed
Computed tomography
tomography
12/13/2014 14
Diagnostic evaluation of a pleural effusion : Initial
testing
12/13/2014 15
Example
Example 01
01
12/13/2014 16
Is
Is it
it transudate
transudate or
or exudate?
exudate?
12/13/2014 18
Is
Is it
it transudate
transudate or
or exudate?
exudate?
Acute diuresis in heart failure can elevate protein levels into the exudative range
12/13/2014 19
Is
Is it
it transudate
transudate or
or exudate?
exudate?
Acute diuresis in heart failure can elevate protein levels into the exudative
range
serum to pleural fluid albumin gradient greater than 1.2 g/dL (12 g/L)
elevated blood N-terminal pro-brain natriuretic peptide (NT-proBNP)
Example 01
Serum albumin 3.5 g/dL and pleural fluid albumin 1.8 g/dL
serum to pleural fluid albumin gradient 3.5-2.0=1.7 (transudative)
12/13/2014 20
Example
Example 02
02
12/13/2014 21
Gross
Gross appearance
appearance
12/13/2014 22
Parapneumonic
Parapneumonic effusion
effusion
Uncomplicated parapneumonic
effusion
pH <7.20
Complicated parapneumonic glucose <60 mg/dL
effusion LDH>1000 IU/L
12/13/2014 23
12/13/2014 24
12/13/2014 25
Thoracic
Thoracic empyema
empyema
12/13/2014 26
Example
Example 03
03
Leakage or rupture
Thoracic lymph node
Antigen and organism
Subdiaphragamatic
focus
Delayed hypersensitivity
Hematogenous
Tuberculous pleural effusion
12/16/2014 29
Example
Example 03
03
12/16/2014 30
Tuberculous
Tuberculous pleural
pleural effusion
effusion
“Even when the AFB smear and culture are negative, compatible routine
studies along with an elevated ADA level may establish a presumptive
diagnosis of tuberculous pleuritis in the right clinical setting”
12/16/2014 31
Tuberculous
Tuberculous pleural
pleural effusion
effusion
Diagnostic work up
Pleural biopsy
12/16/2014 32
Tuberculous
Tuberculous pleural
pleural effusion
effusion
Diagnostic work up
12/16/2014 33
Tuberculous
Tuberculous pleural
pleural effusion
effusion
Treatment
Antituberculous chemotherapy
Treatment response
12/16/2014 34
Example
Example 04
04
12/13/2014 35
Malignancy
Malignancy related
related pleural
pleural effusions
effusions
12/13/2014 36
Example
Example 03
03
Exudative
Lymphocytic
Mesothelial cells >5% (tuberculosis unlikely)
Adenosine deaminase 18 IU/L
12/13/2014 37
Evaluation
Evaluation of
of malignant
malignant pleural
pleural effusion
effusion
Pleural biopsy
12/13/2014 38
Management
Management of
of malignant
malignant pleural
pleural effusions
effusions
12/13/2014 39
Example
Example 05
05
12/13/2014 40
Example
Example 05
05
Exudative
Lymphocytic
Mesothelial cells >5% (tuberculosis unlikely)
Adenosine deaminase 11 IU/L
12/13/2014 41
Left
Left side
side pleural
pleural effusion
effusion with
with high
high amylase
amylase
12/13/2014 42
Management
Management of
of pancreatic
pancreatic pleural
pleural effusion
effusion
Treatment
repeated aspiration
diuretics, octreotide
parenteral nutrition to decrease pancreatic secretion
endoscopically-placed stents
surgery
12/13/2014 43
Example
Example 04
04
Referred to GI surgeon
12/13/2014 44
Thank you
12/13/2014 45