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Anticoagulant, Antithrombotic and Anti-Platelet Drugs: Department of Pharmacology
Anticoagulant, Antithrombotic and Anti-Platelet Drugs: Department of Pharmacology
• Antithrombotic, Antiinfammatory,
Profibrinolytic Properties
• Serious Bleeding is Major Side Effect
Antithrombin III Inhibits the
Following Serine Proteases
• Coagulation • Fibrinolysis
• Surgical Prophylaxis
– 5,000 Units SQ 2 hr preop
– 5,000 Units SQ every 12 hours
• Medical Prophylaxis
– 5,000 Units SQ every 12 hours
• No monitoring required
Indications for and Contraindications to
Parenteral Anticoagulant Agents
Anticoagulant Agent Class Approved & Appropriate Contraindication
Indications
Regional anesthesia
Low-molecular- Prophylaxis in moderate-risk or
Tinzaparin weight heparin high-risk patients, treatment of
(Innohep) venous thromboembolism
Indications for and Contraindications to
Parenteral Anticoagulant Agents (cont’d)
Ardeparin Low-molecular-weight Approved; not being Regional anesthesia
heparin marketed
Prophylaxis in high-
Fondaparinux Synthetic factor Xa Unknown
risk patients?
inhibitor
Heparin-Antibiotic Interactions