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Fatty Acid Beta Oxidation
Fatty Acid Beta Oxidation
Fatty Acid Beta Oxidation
KETOGENESIS
LEARNING OBJECTIVES FOR TODAY:
Blood Circulation
ATP dependent
ACTIVATION: FATTY ACID TO ACYL COA
THIRD PHASE: ENTRY INTO MITOCHONDRIA
TRANSLOCATION OF ACYL COA
Acyl CoA from SCFA/MCFA
can traverse the outer
membrane and inner
mitochondrial membrane
directly
This acyl CoA molecule is the substrate for the next round of
oxidation starting with acyl CoA dehydrogenase
Repetition occurs until all the carbons of the original fatty acyl
CoA are converted to acetyl CoA
In the last round, a four carbon acyl CoA (butyryl CoA) is
cleaved into 2 acetyl CoA
BIOENERGETICS OF FA OXIDATION
Example: Palmitic Acid (16 Carbon fatty
acid)
GLUCONEOGENESIS
ß-oxidation
PYRUVATE ACETYL-CoA
OXALOACETATE
Ketone bodies
CITRATE
Fatty acid oxidation + lack of oxaloacetate
fasting
untreated diabetes
THREE KETONE BODIES
SYNTHESIS OF KETONE BODIES IN THE LIVER
KETONE BODIES AS FUELS
OXIDATION OF KETONE
BODIES IN EXTRAHEPATIC
TISSUES
heart muscle
striatal muscle
kidney
brain
SUMMARY ON KETONE BODIES