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Hormones 1
Hormones 1
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Endocrine hormone molecules are
secreted (released) directly into the blood
stream.
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Chemically, hormones are of four types:
1. Hormonal amine.
2. Peptide, protein, or glycoprotein.
3. Steroid.
4. Eicosanoid.
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1. Hormonal Amines
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2. Steroid Hormones
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Four kinds of steroid hormones differ in
structure and action; they are the
androgens (C19), the estrogens (C18), the
progestins (C21), and the corticosteroids
(C21).
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3. Peptide, Protein, and Glycoprotein
Hormones
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Mechanism of Hormone Action
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Hormone receptors can be classified into
three types on the basis of their locations
in the cell and the types of hormone they
bind:
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Cytosolic receptors, which bind steroid
hormones as they diffuse into the cell.
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Nuclear receptors of
thyroid hormones
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Video
(Thyroxine _ Mechanism of Action
of Thyroid Hormones)
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Steroid Hormone Receptors
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Video
(Steroid Hormones _ Mechanism
of Action)
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Cell Surface Receptors
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G-Protein-Coupled Adenylate Cyclase-
cAMP System
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G-Protein-Coupled Phosphatidylinositol-
Ca2+ Pathway
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Video
(How Hormones Use G-protein
Signaling Pathways_ A Video
Review of the Basics)
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Hypothalamus
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Hypophysiotropic Peptides released by
hypothalamus
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Thyrotropin-releasing hormone (TRH)
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2.Gonadotropin-releasing hormone (GnRH) or
luteinizing hormone-releasing hormone (LHRH)
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4. Growth hormone-releasing hormone
(GHRH)
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5.Somatostatin
Somatostatin (growth hormone release-inhibiting
hormone) is a tetradecapeptide [14 amino acids]
with an intrachain disulfide bridge.
Somatostatin inhibits the synthesis and release of
GH from the somatotropes by neutralizing the
effect of GHRH, an effect mediated by Giα
inhibition of adenylyl cyclase.
Within the hypothalamus, somatostatin inhibits
the release of GHRH by the same mechanism and
therefore exerts an inhibitory effect at two levels
of GH control.
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6.Prolactin-inhibiting hormone (PIH)
It is known as dopamine.
It functions as a neurotransmitter in the CNS
and as a precursor of norepinephrine and
epinephrine in the adrenal medulla.
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Neurohypophyseal Peptides
ADH
(Vasopressin)
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Video
(GTAC - Chemical Signalling_
Antidiuretic hormone (ADH)
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Oxytocin
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The principal action of oxytocin is ejection of milk
from the lactating mammary gland ("milk let-
down"), and it also participates in parturition.
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