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  • Scale-Up Considerations Related To Blending of Solid Oral Dosage Forms

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    Pardhasaradhi Vobenaboina
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    The document discusses key considerations for scaling up blending of solid oral dosage forms, including the types of mixing, principles involved, and parameters like tip speed, rotation rates, fill levels, and operating times that must be evaluated. It also addresses the concepts of critical speed, Froude number, and potential for segregation during or after blending when scaling processes.

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    MD AMEERODDIN.pptx

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    The document discusses key considerations for scaling up blending of solid oral dosage forms, including the types of mixing, principles involved, and parameters like tip speed, rotation rates, fill levels, and operating times that must be evaluated. It also addresses the concepts of critical speed, Froude number, and potential for segregation during or after blending when scaling processes.

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    7 views10 pages

    Scale-Up Considerations Related To Blending of Solid Oral Dosage Forms

    Uploaded by

    Pardhasaradhi Vobenaboina
    The document discusses key considerations for scaling up blending of solid oral dosage forms, including the types of mixing, principles involved, and parameters like tip speed, rotation rates, fill levels, and operating times that must be evaluated. It also addresses the concepts of critical speed, Froude number, and potential for segregation during or after blending when scaling processes.

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    of 10

    A seminar on

    Scale-up Considerations Related To


    Blending Of Solid Oral Dosage Forms

    By Ameeroddin Mohammad

    Neuheit Pharma Technologies Private Ltd.


    Creative solution to human sufferings
    Agenda

    • What is mixing?

    • Types of mixing

    • Principles involved

    • What is tip speed?

    • Scale up considerations

    • Summary
    August 21, 2019 Blending & Mixing 2
    Introduction

    • Material may be
    – Free flowing

    – Cohesive

    August 21, 2019 Blending & Mixing 3


    Contd.

    • Try-it-and-see approach

    August 21, 2019 Blending & Mixing 4


    What is blender’s critical speed?

    It is the speed where


    the tangential
    acceleration caused BLENDER
    by the rotation equals
    the acceleration.

    August 21, 2019 Blending & Mixing 5


    Blending & Mixing

     What rotation rates should be used?

     Should filling levels be the same?

     How long should the blender be operated?

     Are variations to the blender geometry


    between scales acceptable?

    August 21, 2019 Blending & Mixing 6


    What is TIP SPEED?

    August 21, 2019 Blending & Mixing 7


    What is Froude number?

    Fr =[2R]/g

    where,
     is the rotation rate,
    R is the vessel radius, and
    g is the acceleration due to gravity

    August 21, 2019 Blending & Mixing 8


    Segregation

    • May occur
    – Within the bender during mixing

    – After the discharge

    August 21, 2019 Blending & Mixing 9

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