PERANAN PANGAN HAYATI LAUT

PADA PENYAKIT KARDIOVASKULER

DAN DISLIPIDEMIA

Dr. Jamaluddin, M.Kes, Sp.JP, FIHA

• Penyakit kardiovaskuler merupakan
penyebab kematian terbesar diseluruh
dunia
• Penyakit jantung koroner masih
menjadi penyebab kematian tertinggi
• Berbagai upaya telah dilakukan untuk
menurunkan inseden PJK
• Marine omega-3 fatty acids have an
important role in reducing coronary
artery disease (CAD) risk

• This has been established by both

epidemiologic and randomized
intervention trials.
• Omega 3 (EPA dan DHA)  paling bermanfaat
untuk penyakit kardiovaskuler (membantu
mencegah penyakit jantung koroner dan
menghambat progresivitas pjk)

• Sumber  biota laut  disebut omega 3 laut

Rekomendasi American Heart
Association (AHA)
Mechanisms of CAD Protection
 Antiarrhythmic Effects and Prevention of Sudden
Cardiac Death

• can reduce the risk for ventricular fibrillation and

subsequent sudden cardiac death
• Omega-3 fatty acids are incorporated into myocardial
cell membranes where they are a potent inhibitor of
voltage-gated Na+/H+ channels in cardiac
cardiomyocytes,
 preventing calcium overload by maintaining L-type
calcium channels during periods of ischemic stress
 increases the ventricular refractory period and the
electrical threshold required to induce an action
potential-depolarization
Triglyceride Lowering
MOLECULAR BIOLOGY PATHWAY
 Thrombosis and Inflammation

• EPA can reduce CAD risk by effecting

processes that reduce both thrombosis and
inflammation
• As dietary EPA becomes incorporated into
tissue membranes, it becomes a substitute
• for arachidonic acid (AA), an omega-6 fatty
acid that is 20 carbons in length
• AA  thromboxane A2  promotes platelet
aggregation and vasoconstriction

• Conversely, EPA prostaglandin derivatives are of the A

3-series (ie, thromboxane A3), which are less
vasoconstrictive and produce less platelet aggregation

• Likewise, the series of 5 lipoxygenase metabolites (ie,

leukotrienes) derived from EPA have a lower
atherogenic potential than those derived from AA
precursors because they have lesser proinflammatory
effects.
• Marine n-3 fatty acids also decrease
chemoattractant , growth factor and
adhesion molecule production and so could
down-regulate processes leading to leukocyte
and smooth muscle migration into the vessel
wall intima.
 Blood Pressure Lowering
• This effect is likely the result of increased
systemic arterial compliance and improved
endothelial function
Stability of atherosclerotic plaques
Terima kasih