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SKENARIO 1

FARMAKOLOGI
DI BIDANG NON INFEKSI
METYLPREDNISOLON HIGH DOSE, CYCLOPHOSPAMID INJEKSI, FUROSEMID INJEKSI, CAPTOPRIL
PER ORAL, NOCORAPID DAN LEVEMIR
.tg
(b
ko
p
K
n
a
s-im
P
u
8 .
a tg
d
tikA
e
n
rlu (b
o
k
p
K
n
a
-im
s
P
u
8 .
ti rlu
rg
lsC
n
fa
d
ko
u ap
d
A
tik
e
n K
b
s(a
ko
i iu
rT
e
tlm
kg
a t re
rg
C
ls
n
fa
d
o
k o
a
d
liA
k a
iH
tb
re
a
n
o
m i o
rT
e
tlm
g
k rg
ksC
ji)o m
re
a
n
m
skltg k te
iH
tb
re
a
n
o i
T
g
fs s
p
n
ylu
ka
io ji)o e
re
a
n
m
ltg
k a
n
iH
b
l,it io
so
a
rp
n fs ia
p
n
lu
y
a
k k
n
)o
sm
sre n
a
ikd
n
tg
o l,it n
o
s
a
rp fyko
lp
r o
tg
d
sb
o
e
n
p
lia re ,a
s
a
d
ik
n
tg s
io
ti lia
u
d
yra
e
kn
o r k
tg
d
b
s
o
e
n
p srt
d
n
k o ti a
u
d
ra
y
e
n
k e
tig

ANTI KANKER
u
b
e
m
t.g
h
ia
o
n
sd n
lo
b
ru
e
Z
a
g
,in k d
u
b
e
m
t.g
h
ia
o r
tie
u
t ,in
u
h
e
yko
ia
d da
s
lo
b
ru
e
Z
a
g iko
u
b
dd
e
p
l,h
u
n
ro
a t ru
u
h
e
o
k
y
ia si
lo
b
,o a
ke
ia
tp
u
ld
n de
e
p
l,h
u
n
ro tkd
u
h
s n
km
le
fo
d
p
h
a
b ,o l,h
e
k
ia
tp
u
ld a
re
p
rtik b
,.a
ln
m
e s e
km
le
fo
d
p
h
a l
o
,a
d
kjh e
rp
s,d
G
yn
t.a rtik ka
,.a
ln
m e
sp
m
s t.a
n
ie
yo
h
T
a jh tn
k
rp
,d
s
G
n
y ikl
ua
o
ilrn
kp
e
m s rp
n
ie
o
y
h
T kj
sa
l m
n
sig
u
m
a
ro
e uo
o
ilrn
p
k
e h
n
a
e
ye e
la
n
rp
td l ln
n
ig
s
u
m
a
ro rs
o
e ig u
la
n
ru td
h
d
e
tg
a
ea
tru
a
ikn
sp
y
la
n
rp
ru ta
h
d
e
tg d
ye Kanker adalah suatu penyakit dengan ciri ganguan atau kegagalan
ir s
b
n
se
a
o ed
tru
a
n
ik
p r
h
ta
l o
2
a
m
sg
to
n
on
n
h
b
g
.jle
ir a
b
n
e
s
a
l ra
2
a
m
g
s
to
tke
u
k
n
e
mekanisme pengatur multifikasi dan fungsi homeostasisa organisme
oa le
n
s .jle
,g
a
m
iln
d
u
je u
lsn
ikp
m
a
g
n
h
b
g
s h
,g
a
m
iln
d l
e
g
n multiseluler
fp g
ie
u
h
ko
b
n
a je ,ig
n
ls
p
ik
m
a so
n
rl a
n
o
ka
g fp sn
ie
u
h
o
k
b
n m
je
a
hg
syita
g
n
lo rl e
n
o
a
k b
a
fp
h rla o
yto lo
m
ia
e
rg
u
r u
p
lie
n
kta
syita
g
n
yto ta
m
ia
e
rg k
g
h
n sifat umumnya adalah
srtm k
kp
h
in
o r a
p
lie
n
ta tih
m
fo o
h
i,
jtn
e
ksa rtm ta
s
p
k
h
in
fo isro
io
p
e
t
1. pertumbuhan berlebihan
mk
g
u
ra
n
ip
o h
i,
jtn
e
a
s
sg o
ke
b
d
i2
a
rn
g rn
ia
rjn
t,d
mn
g
u
ra
n
ip
gg
s
e
k
b
d
i2
a
m
fa
h
i,
o
in
a
m 2. ganguan diferensiasi
s t,d
p
h
g
2
e
d
iya g ke
ia
rjn n
sg
d
r iy
s.p
zilb
d
n
ka s a
p
h
g
2
e
d
a
r h
s
tig
st
p
a
3. bersifat invasif
itH k
a
e
n
o .p
s
ilb
z
d
n
a
ro o
lksn
ig
ir ig
lu
a
h
e
m
d
itH lb
a
e
n
ro a
n
s
lk
e
s.p
r
tH
o 4. metastatik
t d ir klro
lu
a
h
e
m n
ym
o
h
ka
se
,o s
m
a
irtskb t u
m
y
o
h
a
k
e
,o sm
ra
ie
td
5. memiliki hereditas bawaah
ts irts
e
m
rio
u
n m
a
b
k
kig n
rh
a
o
tp
d tp
o
u
b
ltn
a
e
ts m
e
m
rio
u
ig e
k
rh
a
o
y
a
,o
sa
tn 6. pergeseran metabolisme ke arah pembentukan makro molekul
frg e
ye
tkia d ka
o
u
b
ltn
a n
ih
h tk
m
g
ksb
tn
ia frg a
e
y
ia g
o
n
se ia
ia
to
kn h rg
m
g
b
s
k
tn id
nk
p
istrh
,e eb
s
ia
to
n i
m
g
p ,e
kia
d
ctu
m no
p
trh
is h
e
a
l m
n
d
u
g
ie ph
ia
k
d
tu
c a
rn
p
k ie
slrb l ia
n
d
u
g s
p
i slrb
u
o
a k d i
e
n
s a
ltikn i rsl
u
o
,tp ltik
o
d
a
n s a
n ik
an
e
p
kid
yu ,tp ts
o
d
a a
n
dy
m
e
n
to
a a ,tp
e
p
id
k
u n
aa
m
rg
in
p dp
m
e
n
to d
a
e
bp
tke
g
rd ae
m
rg
in i
d
m
ic rd
a
e bm
e
tk
g a
ae
kfn
d ic e
a b
y d
zh
o
e
b
n a ca
fn
k
an
ko
ie y a
zh
o
e
b n
k ie
n
srd ah
o
k y
ds
a
o k a
n
rd
lr o dn
a k
t lr
o
i. o
n t
, n i.
.tg
(b
ko
p
K
n
a
s-im
P
u
8 .
a tg
d
tikA
e
n
rlu (b
o
k
p
K
n
a
-im
s
P
u
8 .
ti rlu
rg
lsC
n
fa
d
ko
u ap
d
A
tik
e
n K
b
s(a
ko
i iu
rT
e
tlm
kg
a t re
rg
C
ls
n
fa
d
o
k o
a
d
liA
k a
iH
tb
re
a
n
o
m i o
rT
e
tlm
g
k rg
ksC
ji)o m
re
a
n
m
skltg k te
iH
tb
re
a
n
o i
T
g
fs s
p
n
ylu
ka
io ji)o e
re
a
n
m
ltg
k a
n
iH
b
l,it io
so
a
rp
n fs ia
p
n
lu
y
a
k k
n
)o
sm
sre n
a
ikd
n
tg
o l,it n
o
s
a
rp fyko
lp
r o
tg
d
sb
o
e
n
p
lia re ,a
s
a
d
ik
n
tg s
io
ti lia
u
d
yra
e
kn
o r k
tg
d
b
s
o
e
n
p srt
d
n
k o ti a
u
d
ra
y
e
n
k e
tig

ANTI KANKER
u
b
e
m
t.g
h
ia
o
n
sd n
lo
b
ru
e
Z
a
g
,in k d
u
b
e
m
t.g
h
ia
o r
tie
u
t ,in
u
h
e
yko
ia
d da
s
lo
b
ru
e
Z
a
g iko
u
b
dd
e
p
l,h
u
n
ro
a t ru
u
h
e
o
k
y
ia si
lo
b
,o a
ke
ia
tp
u
ld
n de
e
p
l,h
u
n
ro tkd
u
h
s n
km
le
fo
d
p
h
a
b ,o l,h
e
k
ia
tp
u
ld a
re
p
rtik b
,.a
ln
m
e s e
km
le
fo
d
p
h
a l
o
,a
d
kjh e
rp
s,d
G
yn
t.a rtik ka
,.a
ln
m e
sp
m
s t.a
n
ie
yo
h
T
a jh tn
k
rp
,d
s
G
n
y ikl
ua
o
ilrn
kp
e
m s rp
n
ie
o
y
h
T kj
sa
l m
n
sig
u
m
a
ro
e uo
o
ilrn
p
k
e h
n
a
e
ye e
la
n
rp
td l ln
n
ig
s
u
m
a
ro rs
o
ru td e ig
y
la
n
rp u
la
n
h
d
e
tg
a
ea
tru
a
ikn
sp
ir s
b
n
se
a
o
ru ta
h
d
e
tg
ed
tru
a
n
ik
p
d
ye
r
h
ta
Sel tumor dapat berada dalam 3 keadaan :
l o ir a
b
n
e
s
a tke
u
2
a
m
sg
to
n
on
n
h
b
g
.jle
s .jle
,g
a
m
iln
d
u
l ra
2
a
m
g
s
to
oa
n
h
b
g
k
n
e
le
n 1. Siklus Proliferatif (sedang membelah)
je u
lsn
ikp
m
a
g s h
,g
a
m
iln
d l
e
g
n
fp g
ie
u
h
ko
b
n
a
rl a
n
o
ka
g
je ,ig
n
ls
p
ik
m
a
fp sn
ie
u
h
o
k
b
n
so
n
m
je
a 2. Keadaan Istirahat (tidak membelah, G0)
hg
syita
g
n
lo rl e
n
o
a
k b
a
fp
yto lo
m
ia
e
rg
u
r u
p
lie
n
kta
h rla
syita
g
n
yto ta
m
ia
e
rg
r a
o
k
g
h
n
tih
m
3. Secara permanen tidak membelah
srtm k
kp
h
in
o p
lie
n
ta
fo o
h
i,
jtn
e
ksa rtm ta
s
p
k
h
in io
p
e
mk
g
u
ra
n
ip
o fo isro
h
i,
jtn
e
a
s t
sg o
ke
b
d
i2
a
rn mn
g
u
ra
n
ip m
fa
h
i,
g rn
ia
rjn
t,d
s t,d
p
h
g
2
e
d
iya
r iy
s.p
zilb
d
n
ka
gg
s
e
k
b
d
i2
a
g ke
ia
rjn
s a
p
h
g
2
e
d
a
o
in
a
m
n
sg
d
s
tig
Pada saat membelah terdapat beberapa fase yaitu :
r h st
p
a
itH k
a
e
n
o
ro o
lksn
ig
ir ig
lu
a
h
e
m
d
.p
s
ilb
z
d
n
a
itH lb
a
e
n
ro a
n
s
lk
e
s.p
r
tH
o
1. Mitosis (M)
t d ir klro
lu
a
h
e
m n
ym
o
h
ka
se
,o s
m
a
irtskb
ts irts
e
m
rio
u
n
t u
m
y
o
h
a
k
e
,o sm
m
a
b
k
ra
ie
td
2. Paskamitosis (G1)
kig n ts m
e
m
rio
u y
a
,o
rh
a
o
tp
d tp
o
u
b
ltn
a
e
frg e
ye
tkia
ig e
k
rh
a
o
d ka
o
u
b
ltn
a
sa
tn
n
ih 3. Fase sintesis DNA (fase S)
h tk
m
g
ksb
tn
ia frg a
e
y
ia g
o
n
se ia
ia
to
kn
nk
p
istrh
,e
h rg
m
g
b
s
k
tn
eb
s
ia
to
n
id
i
m
g 4. Fase Pramitosis (G2)
p ,e
kia
d
ctu
m no
p
trh
is h
e
a
l m
n
d
u
g
ie ph
ia
k
d
tu
c a
rn
p
k ie
slrb l ia
n
d
u
g s
p
i slrb
u
o
a k d i
e
n
s a
ltikn i rsl
u
o
,tp ltik
o
d
a
n s a
n ik
an
e
p
kid
yu ,tp ts
o
d
a a
n
dy
m
e
n
to
a a ,tp
e
p
id
k
u n
aa
m
rg
in
p dp
m
e
n
to d
a
e
bp
tke
g
rd ae
m
rg
in i
d
m
ic rd
a
e bm
e
tk
g a
ae
kfn
d ic e
a b
y d
zh
o
e
b
n a ca
fn
k
an
ko
ie y a
zh
o
e
b n
k ie
n
srd ah
o
k y
ds
a
o k a
n
rd
lr o dn
a k
t lr
o
i. o
n t
, n i.
.tg
(b
ko
p
K
n
a
s-im
P
u
8 .
a tg
d
tikA
e
n
rlu (b
o
k
p
K
n
a
-im
s
P
u
8 .
ti rlu
rg
lsC
n
fa
d
ko
u ap
d
A
tik
e
n K
b
s(a
ko
i iu
rT
e
tlm
kg
a t re
rg
C
ls
n
fa
d
o
k o
a
d
liA
k a
iH
tb
re
a
n
o
m i o
rT
e
tlm
g
k rg
ksC
ji)o m
re
a
n
m
skltg k te
iH
tb
re
a
n
o i
T
g
fs s
p
n
ylu
ka
io ji)o e
re
a
n
m
ltg
k a
n
iH
b
l,it io
so
a
rp
n fs ia
p
n
lu
y
a
k k
n
)o
sm
sre n
a
ikd
n
tg
o l,it n
o
s
a
rp fyko
lp
r o
tg
d
sb
o
e
n
p
lia re ,a
s
a
d
ik
n
tg s
io
ti lia
u
d
yra
e
kn
o r k
tg
d
b
s
o
e
n
p srt
d
n
k o ti a
u
d
ra
y
e
n
k e
tig

ANTI KANKER
u
b
e
m
t.g
h
ia
o
n
sd n
lo
b
ru
e
Z
a
g
,in k d
u
b
e
m
t.g
h
ia
o r
tie
u
t ,in
u
h
e
yko
ia
d da
s
lo
b
ru
e
Z
a
g iko
u
b
dd
e
p
l,h
u
n
ro
a t ru
u
h
e
o
k
y
ia si
lo
b
,o a
ke
ia
tp
u
ld
n de
e
p
l,h
u
n
ro tkd
u
h
s n
km
le
fo
d
p
h
a
b ,o l,h
e
k
ia
tp
u
ld a
re
p
rtik b
,.a
ln
m
e s e
km
le
fo
d
p
h
a l
o
,a
d
kjh e
rp
s,d
G
yn
t.a rtik ka
,.a
ln
m e
sp
m
s t.a
n
ie
yo
h
T
a jh tn
k
rp
,d
s
G
n
y ikl
ua
o
ilrn
kp
e
m s rp
n
ie
o
y
h
T kj
sa
l m
n
sig
u
m
a
ro
e uo
o
ilrn
p
k
e h
n
a
e
ye e
la
n
rp
td l ln
n
ig
s
u
m
a
ro rs
o
ru td e ig
y
la
n
rp u
la
n
h
d
e
tg
a
ea
tru
a
ikn
sp
ir s
b
n
se
a
o
ru ta
h
d
e
tg
ed
tru
a
n
ik
p
d
ye
r
h
ta
Ditinjau dari siklus sel, obat kanker dibedakan mejadi
l o ir a
b
n
e
s
a tke
u
2
a
m
sg
to
n
on
n
h
b
g
.jle
s .jle
,g
a
m
iln
d
u
l ra
2
a
m
g
s
to
oa
n
h
b
g
k
n
e
le
n 2 yaitu :
je u
lsn
ikp
m
a
g s h
,g
a
m
iln
d l
e
g
n
fp g
ie
u
h
ko
b
n
a je ,ig
n
ls
p
ik
m
a so
n
rl a
n
o
ka
g fp sn
ie
u
h
o
k
b
n m
je
a
hg
syita
g
n
lo rl e
n
o
a
k b
a
fp
yto lo
m
ia
e
rg
u
r u
p
lie
n
kta
h rla
syita
g
n
yto ta
m
ia
e
rg
r a
o
k
g
h
n
tih
m
1. Zat cell cycle-specific (CSS)
srtm k
kp
h
in
o p
lie
n
ta
fo o
h
i,
jtn
e
ksa rtm ta
s
p
k
h
in io
p
e
mk
g
u
ra
n
ip
o fo isro
h
i,
jtn
e
a
s t
sg o
ke
b
d
i2
a
rn mn
g
u
ra
n
ip m
fa
h
i,
g rn
ia
rjn
t,d
s t,d
p
h
g
2
e
d
iya
r iy
s.p
zilb
d
n
ka
gg
s
e
k
b
d
i2
a
g ke
ia
rjn
s a
p
h
g
2
e
d
a
o
in
a
m
n
sg
d
s
tig
contoh : vinkristin, viblastin, merkaptorin, hidroksiurea,
r h st
p
a
itH k
a
e
n
o
ro o
lksn
ig
ir ig
lu
a
h
e
m
d
.p
s
ilb
z
d
n
a
itH lb
a
e
n
ro a
n
s
lk
e
s.p
r
tH
o
dan asparaginase
t d
ym
o
h
ka
se ir klro
lu
a
h
e
m n
,o s
m
a
irtskb t u
m
y
o
h
a
k
e ra
ie
ts irts
e
m
rio
u
n ,o sm
m
a
b
k td
kig n ts m
e
m
rio
u y
a
,o
rh
a
o
tp
d tp
o
u
b
ltn
a
e
frg e
ye
tkia
ig e
k
rh
a
o
d ka
o
u
b
ltn
a
sa
tn
n
ih 2. Zat cell cycle-nonspecific (CCNS)
h tk
m
g
ksb
tn
ia frg a
e
y
ia g
o
n
se ia
ia
to
kn h rg
m
g
b
s
k
tn id
nk
p
istrh
,e eb
s
ia
to
n i
m
g
p ,e
kia
d
ctu
m no
p
trh
is h
e
a
l m
n
d
u
g
ie
k ie
slrb
ph
ia
k
d
tu
c
l ia
n
d
u
g
k d
a
rn
p
s
p
i
e
n
contoh : zat alkilator, antibiotik antikaker (daktinomisin,
i slrb
u
o
a
s a
ltikn
,tp ltik
o
d
a
n
i rsl
u
o
s a
n
,tp ts
ik
a
n
daunorubisin, doksorubisin, plikamisin, mitomisin,
an
e
p
kid
yu o
d
a
dy
m
e
n
to
a
aa
m
rg
in
p
bp
tke
g
rd
a ,tp
e
p
id
k
u
dp
m
e
n
to
ae
m
rg
in
n
d
a
e
i
d
m
sisplatin, prokarbazin, nitrosurea
ic rd
a
e bm
e
tk
g a
ae
kfn
d ic e
a b
y d
zh
o
e
b
n a ca
fn
k
an
ko
ie y a
zh
o
e
b n
k ie
n
srd ah
o
k y
ds
a
o k a
n
rd
lr o dn
a k
t lr
o
i. o
n t
, n i.
.tg
(b
ko
p
K
n
a
s-im
P
u
8 .
a tg
d
tikA
e
n
rlu (b
o
k
p
K
n
a
-im
s
P
u
8 .
ti rlu
rg
lsC
n
fa
d
ko
u ap
d
A
tik
e
n K
b
s(a
ko
i iu
rT
e
tlm
kg
a t re
rg
C
ls
n
fa
d
o
k o
a
d
liA
k a
iH
tb
re
a
n
o
m i o
rT
e
tlm
g
k rg
ksC
ji)o m
re
a
n
m
skltg k te
iH
tb
re
a
n
o i
T
g
fs s
p
n
ylu
ka
io ji)o e
re
a
n
m
ltg
k a
n
iH
b
l,it io
so
a
rp
n fs ia
p
n
lu
y
a
k k
n
)o
sm
sre n
a
ikd
n
tg
o l,it n
o
s
a
rp fyko
lp
r o
tg
d
sb
o
e
n
p
lia re ,a
s
a
d
ik
n
tg s
io
ti lia
u
d
yra
e
kn
o r k
tg
d
b
s
o
e
n
p srt
d
n
k o ti a
u
d
ra
y
e
n
k e
tig

ALKILATOR
u
b
e
m
t.g
h
ia
o
n
sd n
lo
b
ru
e
Z
a
g
,in k d
u
b
e
m
t.g
h
ia
o r
tie
u
t ,in
u
h
e
yko
ia
d da
s
lo
b
ru
e
Z
a
g iko
u
b
dd
e
p
l,h
u
n
ro
a t ru
u
h
e
o
k
y
ia si
lo
b
,o a
ke
ia
tp
u
ld
n de
e
p
l,h
u
n
ro tkd
u
h
s n
km
le
fo
d
p
h
a
b ,o l,h
e
k
ia
tp
u
ld a
re
p
rtik b
,.a
ln
m
e s e
km
le
fo
d
p
h
a l
o
,a
d
kjh e
rp
s,d
G
yn
t.a rtik ka
,.a
ln
m e
sp
m
s t.a
n
ie
yo
h
T
a jh tn
k
rp
,d
s
G
n
y ikl
ua
o
ilrn
kp
e
m s rp
n
ie
o
y
h
T kj
sa
l m
n
sig
u
m
a
ro
e uo
o
ilrn
p
k
e h
n
a
e
ye e
la
n
rp
td l ln
n
ig
s
u
m
a
ro rs
o
ru td e ig
y
la
n
rp u
la
n
h
d
e
tg
a
ea
tru
a
ikn
sp
ir s
b
n
se
a
o
ru ta
h
d
e
tg
ed
tru
a
n
ik
p
d
ye
r
h
ta
Pada Umumnya kerja antikanker berdasarkan atas gangguan pada
l o ir a
b
n
e
s
a tke
u
2
a
m
sg
to
n
on
n
h
b
g
.jle
s .jle
,g
a
m
iln
d
u
l ra
2
a
m
g
s
to
oa
n
h
b
g
k
n
e
le
n salah satu proses sel esensial --> mengganggu sel normal
je u
lsn
ikp
m
a
g s h
,g
a
m
iln
d l
e
g
n
fp g
ie
u
h
ko
b
n
a je ,ig
n
ls
p
ik
m
a so
n
rl a
n
o
ka
g fp sn
ie
u
h
o
k
b
n m
je
a
hg
syita
g
n
lo rl e
n
o
a
k b
a
fp
yto lo
m
ia
e
rg
u
r u
p
lie
n
kta
h rla
syita
g
n
yto ta
m
ia
e
rg
r a
o
k
g
h
n
tih
m
Berbagai alkilator menunjukkan persamaan kerja yaitu melalui
srtm k
kp
h
in
o p
lie
n
ta
fo o
h
i,
jtn
e
ksa
mk
g
u
ra
n
ip
o
rtm ta
s
p
k
h
in
fo isro
h
i,
jtn
e
a
s
mn
io
p
e
t
m
fa
h
i,
pembentukan ion karbonium atau komplek lain yang sangat reaktif.
sg o
ke
b
d
i2
a
rn g
u
ra
n
ip
g rn
ia
rjn
t,d
s t,d
p
h
g
2
e
d
iya
r iy
s.p
zilb
d
n
ka
gg
s
e
k
b
d
i2
a
g ke
ia
rjn
s a
p
h
g
2
e
d
a
o
in
a
m
n
sg
d
s
tig
efek sitostatistk pada alkilasi DNA (perusakan DNA)
itH k
a
e
n
o r h
.p
s
ilb
z
d
n
a st
p
a
ro o
lksn
ig itH lb
a
e
n e
s.p
ir ig
lu
a
h
e
m
d ro a
n
s
lk r
tH
o
t d ir klro
lu
a
h
e
m n
ym
o
h
ka
se
,o s
m
a
irtskb
ts irts
e
m
rio
u
n
t u
m
y
o
h
a
k
e
,o sm
m
a
b
k
ra
ie
td
siklofosfamid --> alkilator yang paling banyak digunakan. obat ini
kig n ts m
e
m
rio
u y
a
,o
rh
a
o
tp
d tp
o
u
b
ltn
a
e
frg e
ye
tkia
ig e
k
rh
a
o
d ka
o
u
b
ltn
a
sa
tn
n
ih bersifat nonspesifik terhadap siklus sel dan efektif pada penyakit
h tk
m
g
ksb
tn
ia frg a
e
y
ia g
o
n
se ia
ia
to
kn
nk
p
istrh
,e
h rg
m
g
b
s
k
tn
eb
s
ia
to
n
id
i
m
g Hodgkin III dan IV, serta limfoma non Hodgkin terutama kombinasi
p ,e
kia
d
ctu
m no
p
trh
is h
e
a
l m
n
d
u
g
ie
k ie
slrb
ph
ia
k
d
tu
c
l ia
n
d
u
g
k d
a
rn
p
s
p
i
e
n
dengan kortikosteroid dan vinkristin
i slrb
u
o
a
s a
ltikn i rsl
u
o
,tp ltik
o
d
a
n s a
n ik
an
e
p
kid
yu ,tp ts
o
d
a a
n
dy
m
e
n
to
a
aa
m
rg
in
p
bp
tke
g
rd
a ,tp
e
p
id
k
u
dp
m
e
n
to
ae
m
rg
in
n
d
a
e
i
d
m
siklofosfamid --> obatprimer neuroblastoma anak
ic rd
a
e bm
e
tk
g a
ae
kfn
d ic e
a b
y d
zh
o
e
b
n a ca
fn
k
an
ko
ie y a
zh
o
e
b n
k ie
n
srd ah
o
k y
ds
a
o k a
n
rd
lr o dn
a k
t lr
o
i. o
n t
, n i.
.tg
(b
ko
p
K
n
a
s-im
P
u
8 .
a tg
d
tikA
e
n
rlu (b
o
k
p
K
n
a
-im
s
P
u
8 .
ti rlu
rg
lsC
n
fa
d
ko
u ap
d
A
tik
e
n K
b
s(a
ko
i iu
rT
e
tlm
kg
a t re
rg
C
ls
n
fa
d
o
k o
a
d
liA
k a
iH
tb
re
a
n
o
m i o
rT
e
tlm
g
k rg
ksC
ji)o m
re
a
n
m
skltg k te
iH
tb
re
a
n
o i
T
g
fs s
p
n
ylu
ka
io ji)o e
re
a
n
m
ltg
k a
n
iH
b
l,it io
so
a
rp
n fs ia
p
n
lu
y
a
k k
n
)o
sm
sre n
a
ikd
n
tg
o l,it n
o
s
a
rp fyko
lp
r o
tg
d
sb
o
e
n
p
lia re ,a
s
a
d
ik
n
tg s
io
ti lia
u
d
yra
e
kn
o r k
tg
d
b
s
o
e
n
p srt
d
n
k o ti a
u
d
ra
y
e
n
k e
tig

ALKILATOR
u
b
e
m
t.g
h
ia
o
n
sd n
lo
b
ru
e
Z
a
g
,in k d
u
b
e
m
t.g
h
ia
o r
tie
u
t ,in
u
h
e
yko
ia
d da
s
lo
b
ru
e
Z
a
g iko
u
b
dd
e
p
l,h
u
n
ro
a t ru
u
h
e
o
k
y
ia si
lo
b
,o a
ke
ia
tp
u
ld
n de
e
p
l,h
u
n
ro tkd
u
h
s n
km
le
fo
d
p
h
a
b ,o l,h
e
k
ia
tp
u
ld a
re
p
rtik b
,.a
ln
m
e s e
km
le
fo
d
p
h
a l
o
,a
d
kjh e
rp
s,d
G
yn
t.a rtik ka
,.a
ln
m e
sp
m
s t.a
n
ie
yo
h
T
a jh tn
k
rp
,d
s
G
n
y ikl
ua
o
ilrn
kp
e
m s rp
n
ie
o
y
h
T kj
sa
l m
n
sig
u
m
a
ro
e uo
o
ilrn
p
k
e h
n
a
e
ye e
la
n
rp
td l ln
n
ig
s
u
m
a
ro rs
o
ru td e ig
y
la
n
rp u
la
n
h
d
e
tg
a
ea
tru
a
ikn
sp
ir s
b
n
se
a
o
ru ta
h
d
e
tg
ed
tru
a
n
ik
p
d
ye
r
h
ta
Kombinasi dengan daktinomisin dan vinkristin --> efektif terhadap
l o ir a
b
n
e
s
a tke
u
2
a
m
sg
to
n
on
n
h
b
g
.jle
s .jle
,g
a
m
iln
d
u
l ra
2
a
m
g
s
to
oa
n
h
b
g
k
n
e
le
n rabdomiosarkoma dan tumor ewing
je u
lsn
ikp
m
a
g s h
,g
a
m
iln
d l
e
g
n
fp g
ie
u
h
ko
b
n
a je ,ig
n
ls
p
ik
m
a so
n
rl a
n
o
ka
g fp sn
ie
u
h
o
k
b
n m
je
a
hg
syita
g
n
lo rl e
n
o
a
k b
a
fp
yto lo
m
ia
e
rg
u
r u
p
lie
n
kta
h rla
syita
g
n
yto ta
m
ia
e
rg
r a
o
k
g
h
n
tih
m
sebagai imunosupressan --> efektif pada artritis rematoid dan sindrom
srtm k
kp
h
in
o p
lie
n
ta
fo o
h
i,
jtn
e
ksa
mk
g
u
ra
n
ip
o
rtm ta
s
p
k
h
in
fo isro
h
i,
jtn
e
a
s
mn
io
p
e
t
m
fa
h
i,
nefrotik pada anak
sg o
ke
b
d
i2
a
rn g
u
ra
n
ip
g rn
ia
rjn
t,d gg
s
e
k
b
d
i2
a o
in
a
m
s t,d
p
h
g
2
e
d
iya g ke
ia
rjn n
sg
d
r iy
s.p
zilb
d
n
ka s a
p
h
g
2
e
d
a s
tig
r h st
p
a
itH k
a
e
n
o
ro o
lksn
ig
ir ig
lu
a
h
e
m
d
.p
s
ilb
z
d
n
a
itH lb
a
e
n
ro a
n
s
lk
e
s.p
r
tH
o
efek samping obat yaitu anoreksia, hemoragi, aminorea, ikterik dan
t d ir klro
lu
a
h
e
m n
ym
o
h
ka
se
,o s
m
a
irtskb
ts irts
e
m
rio
u
n
t u
m
y
o
h
a
k
e
,o sm
m
a
b
k
ra
ie
td
hipoprotrombinea
kig n
rh
a
o
tp ts m
e
m
rio
u y
a
,o
d tp
o
u
b
ltn
a
e ig e
k
rh
a
o sa
tn
frg e
ye
tkia d ka
o
u
b
ltn
a n
ih
h tk
m
g
ksb
tn
ia frg a
e
y
ia g
o
n
se ia
ia
to
kn
nk
p
istrh
,e
h rg
m
g
b
s
k
tn
eb
s
ia
to
n
id
i
m
g absrobsi obat ini melalui saluran cerna, metabolisme melalui hepar
p ,e
kia
d
ctu
m no
p
trh
is h
e
a
l m
n
d
u
g
ie
k ie
slrb
ph
ia
k
d
tu
c
l ia
n
d
u
g
k d
a
rn
p
s
p
i
e
n
dan ekskresi melalui urin
i slrb
u
o
a
s a
ltikn i rsl
u
o
,tp ltik
o
d
a
n s a
n ik
an
e
p
kid
yu ,tp ts
o
d
a a
n
dy
m
e
n
to
a a ,tp
e
p
id
k
u n
aa
m
rg
in
p dp
m
e
n
to d
a
e
bp
tke
g
rd ae
m
rg
in i
d
m
ic rd
a
e bm
e
tk
g a
ae
kfn
d ic e
a b
y d
zh
o
e
b
n a ca
fn
k
an
ko
ie y a
zh
o
e
b n
k ie
n
srd ah
o
k y
ds
a
o k a
n
rd
lr o dn
a k
t lr
o
i. o
n t
, n i.
.tg
(b
ko
p
K
n
a
s-im
P
u
8 .
a tg
d
tikA
e
n
rlu (b
o
k
p
K
n
a
-im
s
P
u
8 .
ti rlu
rg
lsC
n
fa
d
ko
u ap
d
A
tik
e
n K
b
s(a
ko
i iu
rT
e
tlm
kg
a t re
rg
C
ls
n
fa
d
o
k o
a
d
liA
k a
iH
tb
re
a
n
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SIKLOFOSFAMID
u
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p
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Siklofosfamid teredia dalam bentuk kristal 100, 200, 500 mg dan 1,2 g
l o ir a
b
n
e
s
a tke
u
2
a
m
sg
to
n
on
n
h
b
g
.jle
s .jle
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a
m
iln
d
u
l ra
2
a
m
g
s
to
oa
n
h
b
g
k
n
e
le
n untuk suntikan dan tablet 25 dan 50 mg.
je u
lsn
ikp
m
a
g s h
,g
a
m
iln
d l
e
g
n
fp g
ie
u
h
ko
b
n
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n
ls
p
ik
m
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n
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n
o
ka
g fp sn
ie
u
h
o
k
b
n m
je
a
hg
syita
g
n
lo rl e
n
o
a
k b
a
fp
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m
ia
e
rg
u
r u
p
lie
n
kta
h rla
syita
g
n
yto ta
m
ia
e
rg
r a
o
k
g
h
n
tih
m
untuk pasien tanpa kelainan hematologi diberikan 500-1500 mg/m2
srtm k
kp
h
in
o p
lie
n
ta
fo o
h
i,
jtn
e
ksa
mk
g
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ra
n
ip
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p
k
h
in
fo isro
h
i,
jtn
e
a
s
mn
io
p
e
t
m
fa
h
i,
dengan interval 2-4 minggu
sg o
ke
b
d
i2
a
rn g
u
ra
n
ip
g rn
ia
rjn
t,d gg
s
e
k
b
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i2
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in
a
m
s t,d
p
h
g
2
e
d
iya g ke
ia
rjn n
sg
d
r iy
s.p
zilb
d
n
ka s a
p
h
g
2
e
d
a s
tig
r h st
p
a
itH k
a
e
n
o
ro o
lksn
ig
ir ig
lu
a
h
e
m
d
.p
s
ilb
z
d
n
a
itH lb
a
e
n
ro a
n
s
lk
e
s.p
r
tH
o
Dosis oral bersifat individual, umumnya 60-120 mg/m2/hari.
t d
ym
o
h
ka
se ir klro
lu
a
h
e
m n
,o s
m
a
irtskb t u
m
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rh
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ih
h tk
m
g
ksb
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o
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to
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tn id
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p
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to
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ctu
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p
trh
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l m
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d
u
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k
d
tu
c a
rn
p
k ie
slrb l ia
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d
u
g s
p
i slrb
u
o
a k d i
e
n
s a
ltikn i rsl
u
o
,tp ltik
o
d
a
n s a
n ik
an
e
p
kid
yu ,tp ts
o
d
a a
n
dy
m
e
n
to
a a ,tp
e
p
id
k
u n
aa
m
rg
in
p dp
m
e
n
to d
a
e
bp
tke
g
rd ae
m
rg
in i
d
m
ic rd
a
e bm
e
tk
g a
ae
kfn
d ic e
a b
y d
zh
o
e
b
n a ca
fn
k
an
ko
ie y a
zh
o
e
b n
k ie
n
srd ah
o
k y
ds
a
o k a
n
rd
lr o dn
a k
t lr
o
i. o
n t
, n i.
Terima Kasih

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