ALTERNATIVE PATHWAY

 C3

-Not stable, has the ability to activate spontaneously knows as “tick

over” resulting to iC3 molecule.

 iC3

- Has the ability to bind factor B in the presence og magnesium

(only bound factor B can be cleaved by factor D)

-Cannot bind to cell surface

MANNAN LECTIN PATHWAY

*Lectins – proteins that bind to carbohydrates

*MBL – bind to mannose or related sugars such as GLNAC (bacteria,

yeast, viruses, some parasites) in calcium dependent manner

-MBL is an Acute phase protein

*Surface cell + MBL -> activation of MASPs (MASP1/MASP2)

cleaves C2 and C4
 ALTERNATIVE PATHWAYS

-Acts as part of innate or natural immunity

-Important in early defense againts pathogens
-Originally named for protein
 PROPERDIN
-Stabilize the C3 convertase formed
*Triggering substance:
- Bacterial cell walls, fungal cell walls, yeast, viruses, virally infected cells, tumor cells
lines, parasites (some)