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Blood Brain Barrier
Blood Brain Barrier
CEREBRAL EDEMA
Ardik MD
Department of Neurosurgery
Ulin Hospital
Lambung Mangkurat University
Banjarmasin
BLOOD BRAIN BARRIER
Served only to protect the brain from harmful
substances
A single cell layer regulates selectively both
the entry & exit of biologically important
substance in order to control the neural
environment & sustain normal function
Location of the BBB
Composed :
• endothelium of the
cerebral capillary
• & the juxtaposed glial
end feet
Location of the BBB
Electron dense markers
given either
intravascularly or in the
CSF are impeded from
passage endothelial
cleft by interendothelial
tight junction
Location of the BBB
These tight junction
(zonulae occludentes)
appear during
developtment & are
functionally complete
before or shortly after
birth in most species
Small area that have no BBB
- Choroid plexus
- Area postrema
- Median Eminence
- Neurohypophysis
- Pineal Body
- Sub fornical
- Commisural organ
- supraoptic crest
(less tight junction)
General properties of the cerebral
capillary
General properties of the cerebral
capillary
General properties of the cerebral
capillary
Cerebral capillary cell contain
biologically important enzyme
Adenosin triphospatase
(ATPase)
Dehydrogeneses : succinate, other associate with
lactate, glutamat dan glucose,amino acid &
glukose. neurotransmiter
Non amine oxidase. metabolism
Dopa decarboxylase Some of these serve as
Acid phosphatase the basis of transport
Nikotinamide Adenin across the BBB
Dinucleotide (NAD)
Gamma- glutamyl Possess insulin & alpha
transpeptidase receptor
innervation
Have central innervation ( cholinergic and
adrenergic
As well as peripheral innervation
(sympathetic and parasymphatetic)
-receptors :found elsewhere in the
cerebral circulation
-receptor : found at the BBB
Rule of the innervation is poorly
understood
Carrier-mediated BBB movement
Carrier-mediated BBB movement
Radiologic
Imaging
Diagnosis
Radiologic
Imaging
Diagnosis
Radiologic
Imaging
Diagnosis
Radiologic
Imaging
Diagnosis
Radiologic
Imaging
Diagnosis
Radiologic
Imaging
Diagnosis
Radiologic
Imaging
Treatment
Restoration or Improvement of BBB Breakdown
- Barrier intact.