Pathology 정리

김은중 정리
Instructed by 문석균 선생님
• Salivary gland
 Salivary gland - 1 - 01
Normal salivary gland, Parotid gland
 Salivary gland - 1 - 03
Normal salivary gland, Parotid gland

A
D
 Salivary gland - 1 - 04
Normal salivary gland, Submandibular gland

Mucous gland
Serous gland
 Salivary gland - 2 - 01
Sialadenitis, salivary gland
 Salivary gland - 2 - 02
Sialadenitis, salivary gland
 Salivary gland - 3 - 01
Pleomorphic adenoma, Parotid gland
 Salivary gland - 3 - 03
Pleomorphic adenoma, Parotid gland
 Salivary gland - 3 - 05
Pleomorphic adenoma, Parotid gland
 Salivary gland - 3 - 06
Pleomorphic adenoma, Parotid gland
 Salivary gland - 3 - 08
Pleomorphic adenoma, Parotid gland
 Salivary gland - 4 - 01
Mucoepidermoid carcinoma, Salivary gland
 Salivary gland - 4 - 02
Mucoepidermoid carcinoma, Salivary gland
 Salivary gland - 4 - 03
Mucoepidermoid carcinoma, Salivary gland
 Salivary gland - 4 - 06
Mucoepidermoid carcinoma, Salivary gland
 Salivary gland - 5 - 01
Adenoid cystic carcinoma, Salivary gland
 Salivary gland - 5 - 03
Adenoid cystic carcinoma, Salivary gland
 Salivary gland - 5 - 06
Adenoid cystic carcinoma, Salivary gland
 Salivary gland - 5 - 04
Adenoid cystic carcinoma, Salivary gland
 Salivary gland - 5 - 08
Adenoid cystic carcinoma, Salivary gland
 Salivary gland - 5 - 09
Adenoid cystic carcinoma, Salivary gland
 Salivary gland - 5 - 10
Adenoid cystic carcinoma, Salivary gland
Acinic cell ca
 Salivary gland - 6 - 01
Acinic cell carcinoma, Salivary gland
 Salivary gland - 8 - 01
Oncocytoma, Salivary gland
 Salivary gland - 7 - 02
Warthin’s tumor (papillary cystadenoma lyphomatosum), Salivary
gland
 Salivary gland - 7 - 03
Warthin’s tumor (papillary cystadenoma lyphomatosum), Salivary
gland
• Nasopharynx
Keratinizing stratified squamous epithelium

Non-keratinizing stratified squamous epithelium

 Res-15-1.
Keratinizing squamous cell carcinoma, Nasopharynx
 Res-15-2.
Non-keratinizing squamous cell carcinoma, Nasopharynx
 Res-15-4.
Undifferentiated carcinoma (lymphoepithelioma), Nasopharynx
 Res-15-5.
Undifferentiated carcinoma (lymphoepithelioma), Nasopharynx
 Res-15-6.
Undifferentiated carcinoma (lymphoepithelioma), Nasopharynx
 Res-16-2
Squamous cell carcinoma, Larynx

V
 Res-16-4
Squamous cell carcinoma, Larynx
 Res-16-7
Precancerous lesion: Dysplasia, Larynx
 Res-16-8
Precancerous lesion: Carcinoma in situ, Larynx
 Res-16-9
Verrucous carcinoma, Larynx
 Thyroid Gland
Follicular epithelium: cuboida
l to low columnar

Colloid
Follicle
 Normal

Diffusely hyperplastic gland

Small papillae
Scalloped appearance of colloid
 Graves Disease
• Gross Morphology
Symmetrical enlargement with intact capsule
Soft, meaty appearance

• Microscopic Findings
“Too many cells”
Tall, columnar epithelium
Small papillae
Scalloped appearance of colloid
Increased lymphoid tissue in interfollicular stroma
Hashimoto thyroiditis, thyroid, photomicrograph

Lymphocytic infiltrate in the thyroid, micro, with lymphoid

follicle formation, in Hashimoto thyroiditis.
Hashimoto thyroiditis, thyroid, photomicrograph, high power

Lymphocytic infiltrate in Hashimoto thyroiditis, micro, higher

magnification showing Hurthle cells, i.e., altered follicular cells
demonstrating abundant, granular, eosinophilic cytoplasm.
 Germinal center

Small follicles

Mononuclear
inflammatory
infiltrates
 Normal

Hürthle cells

Fibrosis
 Hashimoto’s Thyroiditis
• Gross Morphology
Diffusely enlarged with intact capsule
Pale, gray-tan, firm, somewhat nodular cut surface
• Microscopic Findings
Extensive mononuclear inflammatory infiltration of
the parenchyma
Germinal centers
Small follicles
Epithelial cells with abundant eosinophilic, granular
cytoplasm (Hürthle cells)
Increased connective tissue and fibrosis
 Normal

Mass

Well-defined border

Uniform-appearing
follicles with colloid
Follicular adenoma, thyroid, photomicrograph, low power

This photomicrograph shows an intact fibrous capsule surrounding

the adenoma and separating it from adjacent normal thyroid.
 Follicular Adenoma
• Gross Morphology
– Solitary, spherical, encapsulated lesion
– Well-demarcated from surrounding thyroid parenchy
ma

• Microscopic Findings
– Uniform-appearing follicles containing colloid

Colloid adenoma, fetal adenoma, trabecular adenoma, a

typical adenoma, Hürthle cell adenoma, papillary adeno
ma
Follicular carcinoma
Follicular carcinoma, thyroid, micro

This photmicrograph shows the edge of the lesion with evidence of

capsular invasion (black arrow). This is a well differentiated neoplasm,
i.e., the follicular structure of the parent tissue is preserved; however, the
carcinoma cells show hyperchromatic nuclei.
 Papillary Carcinoma
• Gross Morphology
Solitary or multifocal
Well-circumscribed or infiltrative
Fibrosis and calcification

• Microscopic Findings
Branching papillae with fibrovascular cores
Single/multiple layers of cuboidal epithelial cells
Ground-glass (Orphan Annie) nuclei
Intranuclear inclusions
Nuclear grooves
Psammoma bodies
 Thyroid-20-5
Papillary carcinoma, thyroid gland
 Neck-30-1.
Mycobacterium tuberculosis, lymph node
 Neck-30-2.
Mycobacterium tuberculosis, lymph node
 Neck-30-3.
Mycobacterium tuberculosis, lymph node
 Nose-50-1.
Angiofibroma, nasal cavity
 Nose-51-1.
Fibrous dysplasia, maxilla
 Nose-51-3.
Fibrous dysplasia, maxilla
 Nose-52-1.
Ossifying fibroma
 Nose-52-1.
Ossifying fibroma, maxilla
 Nose-52-1.
Ossifying fibroma, maxilla
Nose-53-1.
Osteoma
 Nose-53-1.
Osteoma, maxilla
 Nose-54-1.
Wegener’s granulomatosis, nasal cavity
 Nose-54-1.
Inverted papilloma, nasal cavity
 Nose-52-1.
Olfaroctory neuroblastoma, nasal cavity
 Nose-52-1.
Aspergillosis, Fungus, nasal cavity
 Nose-52-1.
Mucormycosis, Fungus, nasal cavity
 Nose-52-1.
Candidiasis, Fungus, nasal cavity
 Nose-52-1.
Candidiasis, Fungus, nasal cavity
Aspergilosis
 Charcot-Leyden crystal

Allergic mucin =
Fungal hypae + Eosinophil + Charcot-Leyden crystal
 Ear-80-1.
Cholesterol granuloma, middle ear cavity
 Ear-81-1.
Cholesteatoma, middle ear cavity
 Ear-81-1.
Glomus tumor, middle ear cavity
Neurofibroma vs Schwannoma
 Ear-81-1.
vestibular schwannoma, Internal auditory canal
 Ear-81-1.
menigioma, postreior fossa
Acoustic schwanoma
 Melanoma of skin

Thin ≤ 1.0mm

Intermediate 1.0 - 4.0mm

Thick > 4.0mm

AJCC classification (2002)