Smart Polymers and Their

Applications

INSTRUCTOR: Dr. Van Pham Dan Thuy

STUDENTS: Pham Quoc Phu _B1703290

Nguyen Hong Ngoc_B1710101

 CONTENT

Introduction
Overview of Smart
1 Polymers
Classification
Chitosan
Synthesis
Poly (N-isopropyl
acrylamide) ZnO
Application of
2 Smart Polymers
Drug Delivery

Textile
Engineering

3 Conclusion
 Part 1: Overview of Smart Polymers

1. Introduction
Smart polymers are high – performance polymers that change in the environment like as

Temperature, humidity, pH and chemical compound.

Intensity of light, an electrical, magnetic field and mechanical strength.

Figure 1: The effects of stimuli of smart polymer in

drug delivery
 Part 1: Overview of Smart Polymers
2. Classification
Table 1: Stimuli - Responsive Smart Polymeric Materials
Types of Stimulus Responsive Polymer Material
pH *dendrimers
*poly(L-lysine) ester
*poly(hydroxyproline)
*Lactose-PEG grafted poly(L-lysine) nanoparticle
*poly(L-lysine)-g-poly(histidine)
*poly(propyl acrylic acid)
*polysilamine
*Eudragit S-100
*Eudragit L-100
*Chitosan
*PMAA-PEG copolymer
Light *poly (axit acrylic)
*polyimide
*polyamide
*poly (ethyl acrylate)
*poly ( N - (2-hydroxypropyl) methacrylamide)
*poly ( N -isopropylacrylamide) –PNIPAM
*poly (2-dimetylaminoetyl metacrylat) –PDMAEMA
Temperature PNIPAAm
 Part 1: Overview of Smart Polymers

2.1 pH sensitive smart polymers

The smart polymers contain some groups as functional acid or basic.

Accepting or releasing protons with pH changes.

Application for drug delivery and wastewater.

A B
Figure 1: Structure and states depending on the ionization of the ionic chain
groups of pH - responsive polyelectrolytes (A) poly(acrylic acid) and (B) poly
(N,N-dimethylaminoethylmethacrylate)
 Part 1: Overview of Smart Polymers

2.1.1 Polymers with functional acid groups

The polyacids or polyanion are pH sensitive polymers in their structure contain the acidic groups.
Accept protons at low pH values.

Release protons at high pH values.

For example: Polyacrylic acid can accept ion metals in solution when pH scales increase.
 Part 1: Overview of Smart Polymers

2.1.2 Polymers with functional basic groups

Polybases or polycation contain the positively charged in the basic groups (like amino and heterocylic).
release protons at high pH

accept protons at low pH.

For example: poly(2-vinylpyridine) exist in low pH

 Part 1: Overview of Smart Polymers

2.2 Thermo-responsive polymers

The change of temperature will change the solubility of smart polymers in the solution.

There are two temperature affect to the solubility of smart polymers

Critical solution temperature (LCST).

Upper critical solution temperature (UCST).

 Part 1: Overview of Smart Polymers

2.3 Light sensitive smart polymers

Photosensitive polymers is a polymer that changes its properties when exposed to light.

The molecular change by light is expressed in a change of material properties such as

Shape Optical properties

Humidity Conductivity

Solubility Adhesion
For example: Poly(acrylic acid) is photosensitive polymers
 Part 1: Overview of Smart Polymers

2.4 Magnetic sensitive smart polymers

The magnetic sensitive polymers can associate with nano or microsized solid materials and
apply for the new technology.

Apply in drug delivery.

Some metals like cobalt, ferrite and carbonyl iron are magnetic.
Biocompatible Non-immunogenic

Non-toxic
For example: Poly(3,4-ethylenedioxythiophene) (PEDOT) is magnetic sensitive polymers
 Part 1: Overview of Smart Polymers

3. Synthesis of Smart Polymers

Chitosan and poly (N-isopropyl acrylamide) ZnO nanocomposite are one part of the smart
polymers which will be presented the following.
3.1 Synthesis of Chitosan in pH-sensitive

Chitosan is formed from units of D-glucosamine and N-acetyl-D-glucosamine by (1,4

-β)-linked.
Chitosan has NH2 and OH groups have many lone pair electron.

Chitosan can be hydrolyzed in acid solution.

 Part 1: Overview of Smart Polymers

There are manily two methods to synthesis of chitosan

a. Coacervation/Precipitation b. Emulsion-droplet coalescence

The Spraying
Equipment Valve

Polyanion The impeller

solution
The Chitosan solution

Chitosan Nano – Chitosan

solution particles

Base solution
 Part 1: Overview of Smart Polymers

3.2 Synthesis of poly( N-isopropyl acrylamide) ZnO composite in temperature-

responsive
The polymerization of N-isopropylacrylamide will form the poly(N-isopropylacrylamide)
with the catalyst is azobisisobutyronitrile (AIBN).

Figure 2: The equation of Poly(N-isopropyl

acrylamide) by the free radical mechanism
 Part 1: Overview of Smart Polymers

There are mainly three methods to synthesis of poly (N-isopropyl acrylamide)

ZnO nanocomposite .
a. Synthesis of ZnO nanoparticles
Zn(NO3)2
NaOH

Neutralizing to pH values
of 12
Mixing and heating to 70
°C on magnetic stirrer
Separating the solids by
centrifugation

Washing the solids with

deionized water and ethanol

Drying

Powder
 Part 1: Overview of Smart Polymers

b. Synthesis of ZnO-PNIPAAm by emulsion polymerization

NiPAM, ZnO
nanoparticles, BIS,
SDS and deionised
water
Mixing and Heating to 70
°C
Dissolving and adding
APS in the reaction vessel

Washing the prepared

nanocomposite with
deionized water

Separating the ZnO-

PNIPAAm by centrifugation

Drying

Powder
 Part 1: Overview of Smart Polymers
c. Synthesis of ZnO-PNIPAAm by precipitation.

ZnO nanoparticles,
deionised water and
PNIPAAm

Mixing, Adding NH4OH and Stirring

for 30 min at 70 °C

Separating the ZnO-PNIPAAm by

centrifugation

Washing and Drying

Powder
 Part 1: Overview of Smart Polymers

d. Synthesis of ZnO-PNIPAAm by physical addition.

ZnO nanoparticles,
deionised water and
PNIPAAm

Mixing and Stirring for 30 min at

70 °C

Separating the ZnO-PNIPAAm by

centrifugation

Washing and Drying

Powder
 Part 2: Application of Smart Polymers

1. Application of chitosan in pH-sensitive

Controll formulations in melanoma.

Important process in high acidic stomach.
Increasingly dissolution rate of drugs.
 Part 2: Application of Smart Polymers
2. Application of Poly (N-Isopropylacrylamide) Zno Nanocomposites for
Textile by thermo responsive polymer.
Poly (N–isopropylacryl amide) PNIPAM has lower critical solution temperature (LCST)
at around 32ºC.
Apply textile applications because it is close to the body temperature (37°C).

We choose ZnO because it have two special character such as

Antibacterial properties

UV blocking properties
Inorganic UV blockers are preferable to organic UV blockers because
Non toxic.

Chemically stable under exposure to both high temperature and UV radiations.

 Part 2: Application of Smart Polymers

The process of the coating of the cotton fabric with PNIPAM ZnO
nanocomposite is prepared in the following

The cotton fabric was cut in samples of 70 g each.

Then the samples were introduced in the solutions of ZnO – PNIPAM.

The fabric solutions were homogenized for 30 min in the ultrasound apparel.

When taking the samples of solution they were passed in foulard with pressure of 4,1
bar and velocity of 2,54 m/min.

Finally, the samples are air dried.

Thanks for your
attention!!!