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Chapter 02.pe
Chapter 02.pe
• Drug half-life
• Site of excretion
• Critical concentration
– The amount of a drug that is needed to cause a
therapeutic effect
• Loading dose
– A higher dose than that usually used for
treatment
• Dynamic equilibrium
– The actual concentration that a drug reaches in
the body
Copyright © 2008 Lippincott Williams & Wilkins.
Dynamic Equilibrium
• The actual amount of drug that reaches the body
results in a dynamic equilibrium
– Absorption
– Distribution
– Biotransformation
– Excretion
Copyright © 2008 Lippincott Williams & Wilkins.
Absorption
• Administration
• First-pass effect
• Protein binding
• Blood–brain barrier
• Placenta/breast milk