Ewing Sarcoma (ES)

Defenition
Ewing’s Sarcoma is a type of small round blue
cell tumors.
Ewing Sarcoma / Ewing Sarcoma (ES) is a type of
tumor that has a high degree of malignancy and
is derived from primitive neural cells.
 Epidemiology
• ES is the second most common bone malignancy found in
children.
• ES cases are more common in white races than in Asia.
• ES is the third most primary bone malignancy after multiple
myeloma and osteosarcoma.
• According to the European Intergroup Cooperative Ewing
Sarcoma Study Group (EICESS) the most common
predilection of ES was pelvis (24.7%), femur (16.4%), below
the knee (16.7%), ribs (12.1%), and humerus (4.8%).
• Most cases of ES are found in the second decade of life.
• The frequency of ES events in men is slightly more common
than in women (1.31.5: 1).
 Risk Factor
• Parental exposure to pesticides, solvents and
work in agriculture and agriculture.
• Hernias, both inguinal and umbilical
• Increased age of mother and father at the
time of conception.
 Clinical Manifestation
• mild pain that disappears.
• Pain in spinal and pelvic tumors is usually
accompanied by paraesthesia.
• edema and inflammation at the location of the
lesion.
• Fever.
• Anemia.
• decreased appetite.
• weight.
 Diagnosis
Laboratory examination
- general check up
- lactate dehydrogenase (LDH)
- level alkaline phosphatase (ALP).
In the case of ES, non-specific inflammatory
symptoms are often found, such as an increase
in sedimentation rate (LED), leukocytosis and
elevated LDH levels.
Radiological
examination:
- Plain Photo Immunohistochemical
- CT Scan examination:
- MRI to distinguish ES from
- PET Scan other small round-cell
Anatomical Pathology: tumors.
- Incision biopsy
- Fine needle biopsy
- Core biopsy
Stadium
 Treatment
- Chemotherapy
- Radiotherapy
- Surgery