Conventional drug delivery systems cause fluctuations in drug levels due to immediate release. Novel drug delivery systems (NDDS) aim to maintain therapeutic drug concentrations over extended periods through controlled release. NDDS provide site-specific drug delivery for both acute and chronic therapies. Nanoparticles are widely researched as NDDS carriers due to their small size and large surface area, which can improve drug absorption and protection. Oral insulin delivery remains a challenge but nanocarriers show promise for protecting insulin and increasing its oral bioavailability. Polymeric nanoparticles are investigated as vaccine delivery systems to make antigens long-acting.
Original Description:
An overview of novel drug delivery system
Original Title
Novel Drug Delivery - by Arup chakraborty B pharmacy graduate
Conventional drug delivery systems cause fluctuations in drug levels due to immediate release. Novel drug delivery systems (NDDS) aim to maintain therapeutic drug concentrations over extended periods through controlled release. NDDS provide site-specific drug delivery for both acute and chronic therapies. Nanoparticles are widely researched as NDDS carriers due to their small size and large surface area, which can improve drug absorption and protection. Oral insulin delivery remains a challenge but nanocarriers show promise for protecting insulin and increasing its oral bioavailability. Polymeric nanoparticles are investigated as vaccine delivery systems to make antigens long-acting.
Conventional drug delivery systems cause fluctuations in drug levels due to immediate release. Novel drug delivery systems (NDDS) aim to maintain therapeutic drug concentrations over extended periods through controlled release. NDDS provide site-specific drug delivery for both acute and chronic therapies. Nanoparticles are widely researched as NDDS carriers due to their small size and large surface area, which can improve drug absorption and protection. Oral insulin delivery remains a challenge but nanocarriers show promise for protecting insulin and increasing its oral bioavailability. Polymeric nanoparticles are investigated as vaccine delivery systems to make antigens long-acting.
The conventional dosage forms provide drug release immediately and it causes fluctuation of drug level in blood depending upon dosage form.
Therefore to maintain the drug concentration within
therapeutically effective range need novel drug delivery system. “Novel Drug delivery System (NDDS) refers to the approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effects. Advantages of NDDS Optimum dose at the right time and right location. Efficient use of expensive drugs, excipients and reduction in production cost. Beneficial to patients, better therapy, improved comfort and standard of living. SR – Release of initial dose & further prolonged release of drug. Also called extended release, delayed release, prolonged release. SR means slow release of a drug substance from a dosage form to maintain therapeutic response for extended period (8-12hrs). Time depends on dosage form. e.g., Aspirin SR Tablet, Zuclopenthixol Depot Injection etc.
CR – Release of drug in controlled release for long
periods. In this the rate or speed at which the drug is released is controlled. e.g., Adalat CR (Nifidipine). Physicochemical properties of a drug Route of administration Acute / Chronic therapy Target sites The Patient The disease state/level 1.Matrix Diffusion Types- ◦ Rigid Matrix Diffusion. ◦ Swellable Matrix Diffusion ◦ Reservoir System 2.Dissolution Matrix Type- ◦ Encapsulation 3.Dissolution & Diffusion Controlled Release System 4. Water penetration/Osmotic Pressure Controlled NDDS 5.Chemically controlled NDDS Nanosomes Liposomes Niosomes Nanoparticle Nanosphere Microsphere Microparticle Microemulsion Nanosuspension Micelles • Diabetes is a disorder related to the deficiency in the secretion or action of insulin - a peptide hormone synthesized by the β cells of islets of pancreas. • Insulin is given by the subcutaneous (SC) route. Patient non- compliance is frequent with the SC route. • To remove the hurdle related to oral insulin delivery various efforts have been made. Thus, oral insulin is a dream of patients. • Nanocarriers have been garnering more attention recently because of their size in nano range and greater surface area. These characteristics improve their absorption in contrast to bigger carriers. These novel formulations improve bioavailability; absorption problems associated with insulin and give protection from enzymatic degradation. • At present, researchers from both industries as well as academics are working on oral insulin. With this struggle, the dream of researcher to deliver insulin orally will turn out to be a reality in the future. • Nanotechnology plays a significant role in drug development. • As carriers, polymeric nanoparticles can deliver vaccine antigens, proteins, and drugs to the desired site of action. • Nonmaterial's are widely used in vaccine delivery systems because nanomaterials can make the vaccine antigen long- acting. • Some biodegradable polymer materials such as natural polymeric nanomaterials, chemically synthesized polymer materials, and biosynthesized polymeric materials, and points out the advantages and the direction of research on degradable polymeric materials. • Polymer-based nanomaterials have great potential for the development of novel vaccines and drug systems for certain needs, including single-dose and needle-free deliveries of vaccine antigens and drugs in the future.
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