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Atrial Fibrillation Is Associated With Reduced Brain Volume and Cognitive Function Independent of Cerebral Infarcts
Atrial Fibrillation Is Associated With Reduced Brain Volume and Cognitive Function Independent of Cerebral Infarcts
Atrial Fibrillation Is Associated With Reduced Brain Volume and Cognitive Function Independent of Cerebral Infarcts
Duration of
Hospital in AF :
Reviewing Reykjavik Excluded :
hospital & ICD-9 code from january Reviewing -Paroxysmal AF < 4 Calculated
private 427.9 / ICD- 1, 1987 – 12-lead - Persistent/ weeks from date of
physician’s 10 code I48 day of the ECG open heart 1st dx/ -
permanent date of the
records study surgery
examination study
examination
Potential Confounders
• Age
• Sex
Questionnare •
•
Education level
Smoking status
• Alcohol consumption
Geriatric
depression • High depressive symptomatology
scale
Sex-spesific composite
Averaging the Z scores
The battery of cognitive measures were computed
across the tests in each
test (MEM, SP, EF) by converting raw scores
composite
standarized z score
Significance was set at P<0.05 for all models. All analyses were performed
using SAS version 9.2 (SAS Institute)
Analytical Sample
3960
4251 ( 3 cognitive
(demented domain test
participants & composite
4569 scores)
missing
( Brain MRI) information
regarding
5706 cognitive
(inform status
consent)
5764
( AGES-
Reykjavik
study)
Results
Discussion