KONSEP HEMOSTASIS

Eno Ayu Ningsih Zega

Imanuel Simarmata
 DEFENISI HEMOSTASIS

Hemostasis adalah kemampuan alami untuk

menghentikan perdarahan pada lokasi luka oleh spasme
pembuluh darah, adhesi trombosit dan keterlibatan aktif
faktor koagulasi, adanya koordinasi dari endotel
pembuluh darah, agregasi trombosit dan aktivasi jalur
koagulasi. Fungsi utama mekanisme hemostasis ini
adalah menjaga keenceran darah (blood fluidity) sehingga
darah dapat mengalir dalam sirkulasi dengan baik, serta
membentuk thrombus sementara atau hemostatic
thrombus pada dinding pembuluh darah yang mengalami
kerusakan (vascular injury).
Trombosit Sistem
(Platelet) Vaskular

Sistem
Koagulasi &
Fibrinolisis

Hemostasis
 *Vitamin K required.
Clotting Factors (Table 1)
Factor Name Type of Source Pathway(s)
number molecule
I Fibrinogen Plasma Liver Common;
protein converted
into fibrin
II Prothrombin Plasma Liver* Common;
protein converted
into thrombin
III Tissue Lipoprotein Damaged Extrinsic
thromboplasti mixture cells and
n or tissue platelets
factor
IV Calcium ions Inorganic Diet, Entire
ions in platelets, process
V Proaccelerin Plasma protein Liver, platelets Extrinsic and
intrinsic
VI Not used Not used Not used Not used
VII Proconvertin Plasma protein Liver * Extrinsic

VIII Antihemolytic Plasma protein Platelets and Intrinsic;

factor A factor endothelial deficiency
cells results in
hemophilia A

IX Antihemolytic Plasma protein Liver* Intrinsic;

factor B deficiency
(plasma results in
thromboplastin hemophilia B
component)
X Stuart–Prower Protein Liver* Extrinsic and
factor intrinsic
(thrombokinase

XI Antihemolytic Plasma protein Liver Intrinsic;

factor C deficiency
(plasma results in
thromboplastin hemophilia C
antecedent)

XII Hageman factor Plasma protein Liver Intrinsic;

initiates
clotting in vitro
also activates
plasmin

XIII Fibrin- Plasma protein Liver, platelets Stabilizes

stabilizing fibrin; slows
factor fibrinolysis