Professional Documents
Culture Documents
Alcohols
Alcohols
Alcohols
(Methanol)
(Ethanol)
How Manufactured ?
• Fermentation – Sugar to Alcohol and Carbon
dioxide
C6H12O6→ 2(CH3-CH2-OH) + 2CO2
(Yeasts +sugar + water = CO2 + ethanol)
Convertase
Starch Maltose
• Commercially - obtained from Mollases
Alcoholic Beverages
Malted Liquors: Fermentation of germinating cereals (malts) –
mostly Barley – Beers (3-6%)
Wines: fermentation of Natural Sugars – grapes, apples and
other fruits
No distillation, <15%
Fortified (port) – up to 22%
Champagne – 12-16% (effervescent wine)
Spirits – Rum, Whisky, Brandy and Gin
40 - 55% v/v
Standard 42.8% v/v or 37% w/w
Sources:
Whiskey - distilled grain
Rum - distilled molasses
Gin – any sugar source
Brandy – Distilled wine (Grapes)
Vodka – fermentation of any of grain, rye, wheat, potatoes, grapes, sugar beet or mollases
Alcohol – Percentage Calculations
Alcohol content of beverages:
specific gravity of alcohol is 79
Therefore, 1 litre alcohol weighs 790g
Percent may be by weight or by volume
By volume:
1 litre alcohol add 1 litre water = 50% (vol)
By weight:
1 litre alcohol (790g), add 790g water = 50%
(weight)
+ =
1 kilo water 1 kilo alcohol
2 kilos 50% (weight)
Sex - Aphrodisiac
Absorption
Elimination
Urinary Excretion
Exhalation
Metabolism
Metabolism I
H H H
ADH
H C C OH H C C =O
H H H H
Ethanol Acetaldehyde
(ADH – Alcohol Dehydrogenase)
Metabolism II
H H
ALDH
H C C =O H C C =O
H H H OH
Acetaldehyde Acetate
(ALDH – Acetaldehyde Dehydrogenase)
Metabolism III
80-90% Metabolized
Also metabolized in small amounts by hepatic
microsomal enzyme
Rate is constant (not increased by
concentrations in the blood) – zero order (8-12
ml/H of absolute alcohol)
About 30 ml (1 oz) in 3 hours
Concentration in exhaled air is 0.05% of blood
concentration – used in medico legal purposes
Adverse Effects of Alcohol
Acute Effects
Nausea, Vomiting, hangover and traffic accidents
CNS Depressant
Depression of inhibitory control
Vasodilatation, warm, flushed, reddish skin
Emotional outbursts
Decreased memory & concentration
Poor judgment
Decreased reflexes
Decreased sexual response
Adverse Effects of Alcohol –
contd.
Acute Alcohol Intoxication:
Estimated ED50: 150 mg/100 ml and LD50 = 500
mg/100ml
Therapeutic index about 3.5
Hypotension, hypoglycemia, respiratory depression
coma and death
Death due to respiratory depression or inhaled vomit
Treatment:
Gastric lavage
Endotracheal intubations
Fluid and electrolyte balance
Glucose infusion
Thiamine injection 100 mg in 500 ml of glucose IV
Haemodialysis
Consequences of acute
Alcohol intoxication - images
Hangover
Toxic Effects - Chronic
Alcoholism
GIT:
Gastritis and damage to the mucosa –
anaemia
Intestinal damage: Lack of absorption -
Deficiency of water soluble vitamins and
amino acids (protein deficiency)
Less or no food intake (enough calorie) -
Vitamin and Protein deficiency
(Q. Is Alcohol a total food ? Answer: No -
Lacking in total food value)
Chronic Alcoholism – contd.
Liver cirrhosis – scarring of
liver
Usually fatal if drinking
is not stopped
Fatty infiltration
(excess in NADH)
Oxidative stress and
cellular necrosis
Damage to
hepatocytes and
inflammation –
aldehyde
Glutathione
depletion
Microsomal enzyme
induction
Chronic Alcoholism – contd.
Reproduction
Alcohol is a teratogen, it causes birth
defects.
Fetal Alcohol Syndrome (FAS) or Fetal
Alcohol Effects (FAE), or Alcohol-Related
Birth Defects (ARBD)
Symptoms include retardation, poor
coordination, loss of muscle tone, low birth
weight, slow growth, malformation of internal
organs and peculiar facial characteristics
Fetal Alcohol Syndrome (FAS)
Characteristics
Growth retardation
Facial malformations
Small head
Greatly reduce
intelligence
Chronic Alcoholism - features
• Craving: A strong need, or compulsion, to drink
• Loss of control: The inability to limit one’s drinking on any given
occasion
• Tolerance: The need to drink greater amounts of alcohol in order to
“get high” – pharmacokinetic or cellular tolerance
• Physical dependence: Withdrawal symptoms, such as nausea,
sweating, shakiness, sleep impairment, hallucinations, delirium
tremens and anxiety, occur when alcohol use is stopped after a
period of heavy drinking
• Withdrawal syndromes: long acting BZDs like chlordizepoxide
and diazepam
• Naltrexone (50 mg)
Ethanol – Usefulness:
1. Local:
antiseptic, rubefacient and counterirritant in sparins
and to prevent bedsores
antiperspirant and aftershave
Alcohol sponges – to reduce body temperature
2. Appetite stimulant and carminative: 30 – 60 ml of 7-10%
3. Neuralgias: severe cancer pain – injection round the
nerve
4. Protection from cold
5. Alcohol may have a protective effect from heart attack
and stroke - frugivores
6. Methanol Poisoning
Disulfiram (Antabuse)
Internationally marketed as antabuse
ALDH enzyme inhibitor
Alcohol + disulfiram rise in concentration of aldehyde in
blood and tissue distressing aldehyde syndrome
Symptoms: flushing, burning sensation, throbbing headache,
perspiration, dizziness, vomiting, visual disturbance, mental
confusion, fainting and circulatory collapse
Uses: aversion technique in chronic alcoholics: only to
motivated persons
Technique: abstain alcohol overnight and start with 1 gm on
day 1 followed by 0.75 gm next day and 0.50 gm next day and
so on. Effects start within few hrs of 1st dose and lasts for 2
weeks
Mechanism: irreversible inhibition of ALDH and synthesis of
new enzyme takes time and thus person resolves not to drink
for distressing symptoms
Available as 250 mg tablets
Ethanol as Antidote
Methanol, Ethylene glycol, Diethylene glycol
Methanol poisoning – toxicological importance –
unscrupulous mixing with alcoholic beverages
Formic acid is toxic: above 50 mg/dl, lethal dose 75 – 100
ml, even 15 ml can cause blindness
ADH ALDH
Methanol formaldehyde Formic acid