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    Epstein Barr Virus (EBV) is a herpesvirus that is universally acquired by age 3-4 and is the cause of infectious mononucleosis. It is transmitted through oral secretions and body fluids. EBV has a double-stranded DNA genome and its major structural components include capsid proteins of 160, 47, and 28 kD and tegument proteins of 152 kD. EBV establishes lifelong latency in B cells and has been linked to several cancers like Burkitt's lymphoma, Hodgkin's disease, T-cell lymphomas, and nasopharyngeal carcinoma. While treatment is usually supportive, prevention focuses on minimizing exposure and developing effective vaccines.

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    Epstein Barr Virus (EBV) is a herpesvirus that is universally acquired by age 3-4 and is the cause of infectious mononucleosis. It is transmitted through oral secretions and body fluids. EBV has a double-stranded DNA genome and its major structural components include capsid proteins of 160, 47, and 28 kD and tegument proteins of 152 kD. EBV establishes lifelong latency in B cells and has been linked to several cancers like Burkitt's lymphoma, Hodgkin's disease, T-cell lymphomas, and nasopharyngeal carcinoma. While treatment is usually supportive, prevention focuses on minimizing exposure and developing effective vaccines.

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    © All Rights Reserved
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    32 views11 pages

    Muzzammal Alfath - EBV

    Uploaded by

    muzzammalalfath
    Epstein Barr Virus (EBV) is a herpesvirus that is universally acquired by age 3-4 and is the cause of infectious mononucleosis. It is transmitted through oral secretions and body fluids. EBV has a double-stranded DNA genome and its major structural components include capsid proteins of 160, 47, and 28 kD and tegument proteins of 152 kD. EBV establishes lifelong latency in B cells and has been linked to several cancers like Burkitt's lymphoma, Hodgkin's disease, T-cell lymphomas, and nasopharyngeal carcinoma. While treatment is usually supportive, prevention focuses on minimizing exposure and developing effective vaccines.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    of 11

    Epstein Barr Virus

    Overview

    EBV is now the prototype of the gamma subfamily of


    potentially oncogenic herpesviruses.

    Transmission Epidemiology

    Most frequently  •Male = Female


    oropharyngeal secretion •Universal
    (ex: Intimate kissing), seroconversion :
    body fluid Age 3–4 years
    Virus Structure
    • Double-stranded DNA
    • Major EBV capsid proteins : 160, 47, and 28 kd,
    • Major Tegument proteins : 152 kd,
    • Most Abundant EBV envelope : 350/220
    Patricia G. Spear, and Richard Longnecker J. Virol.
    2003;77:10179-10185
    Pathogenesis of EBV Infection
    ANTIBODY RESPONSES TO
    INFECTION
    EBV Latency Protein
    DISEASES ASSOCIATED WITH
    EPSTEIN-BARR VIRUS
    • Infectious Mononucleosis
    • X-linked Lymphoproliferative Syndrome
    and Fatal Infectious Mononucleosis
    • Virus-Associated Hemophagocytic
    Syndrome
    • Burkitt's Lymphoma
    • Hodgkin's Disease
    • T-Cell Lymphomas
    • Nasopharyngeal Carcinoma
    Treatment
    • Symptomatic Management
    • Antiviral Drugs

    Prevention
    • Minimizing Exposure to EBV
    • Antiviral Prophylaxis
    • Vaccines

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