Introduction of Drug Delivery Polymer

 The drug delivery may be steady, controlled, or targeted drug

delivery and is commonly used methods.
 Solutions, lotions, mixtures, creams, pastes, ointments,
powder, injectables, pills, immediate release capsules and
tablets, etc. and so on to treat various diseases.
 The link between the body and the sensor would allow critical
information to be passed from the body to the chip.
 The sensors would measure following signals pH, analytes,
and pressure of the tissues and body fluids.
 A major advancement in the future will be the development
of a continuous glucose sensor to treat diabetes
 Source of drug
Drugs are obtained from six major sources:
 Plant sources
 Animal sources
 Mineral sources
 Semisynthetic sources/ Synthetic sources
 Microbiological sources
 Genetic Engineering (Recombinant DNA technology)
 Classification of polymers
Based on source:
 Natural:- Chitosan, Alginate, Gelatin, Albumin, Collagen,
Dextran
 Semi-Synthetic:- Hydroxy Propyl Methyl Cellulose (HPMC),
Methyl Cellulose (MC), Hydroxy Propyl Cellulose (HPC)
 Synthetic:- Polyethylene, Polylactic acid, Polypropylene,
Polyglycolic acid, PolyhydroxyButyrate
 Role of polymers in drug delivery
 Polymers including polyvinyl‐ pyrrolidone and hydroxy propyl
methylcellulose (HPMC) find uses as binders that aid the
formation of granules that improve the flow and compaction
properties of tablet formulations prior to tableting.
 Capsules: Many of the polymeric excipients used to “bulk
out” capsule fills are the same as those used in immediate
release tablets.
 Gelatin: Has been used almost exclusively as a shell material
for hard (two‐piece) and soft (one‐piece) capsules.
Soft and Hard Gelatin capsule
 APPLICATIONS OF POLYMERS IN DRUG
DELIVERY

Application in conventional dosage forms:

 Tablets: As binders to mask unpleasant taste for enteric
coated tablets
 Liquids:- Viscosity enhancers For controlling the flow
 Semisolids:- In gel preparation
 In Ointments
 Introduction
Principles of Controlled Drug Delivery
The Progestasert System
1) Reservoir Designed Transdermal Patches
2) Matrix Systems
3) Stimulus Responsive Drug Release
4) Ultrasound Responsive Drug Release
5) Temperature Responsive Drug Release
6) pH Responsive Drug Release
7) Electric Current Responsive Drug Release
8) Polymer-Drug Conjugates