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Cibis Iii
Cibis Iii
Cibis Iii
Presented at
The European Society of Cardiology
Hot Line Session 2005
Presented by Dr. Ronnie Willenheimer
CIBIS III Trial
1010 patients > 65 years with mild to moderate CHF (NYHA class II or III) and LV ejection
fraction < 35% in 3 months prior to randomization, clinically stable CHF for 7 days
Randomized
32% female, mean age 72 years, mean follow-up 1.22 years
13% received aldosterone-receptor blocker and 84% diuretic
45
• Study drug discontinuation
30 during the monotherapy arm
occurred in 6.9% of the
15 bisoprolol-first strategy and
9.7% of the enalapril-first
0 strategy