Chronic Kidney Disease

Denny Hartanto
Helen Widjaja
Saint William Moningka
Definisi
loss of renal function over time. This leads to a
decreased ability to remove waste products from
the body and perform homeostatic functions.
(KDIGO 2019)
Definisi KLINIS CKD
GFR of less than 60 ml/minute per 1.73m2 per body surface area
(normal is 125ml/min) .
GFR Calculator: http://www.kidney.org/professionals/kdoqi/gfr_calculator.cfm

Presence of kidney damage,

regardless of the cause,

for three or more months .

Risk Factors
Age of more than 60 years

Hypertension and Diabetes

Race and ethnicity
Responsible for 2/3 of cases
Highest incidence is for
Cardiovascular disease African Americans

Family history of the disease. Hispanics have higher

incidence rates of ESRD
than non-Hispanics.
Symptoms

Hematuria Signs of uremia

Flank pain Lethargy and fatigue
Edema Loss of appetite
Hypertension
If asymptomatic may have elevated serum creatinine
concentration or an abnormal urinalysis
Morphological Changes
Fibrosis

Loss of renal cells mainly by apoptosis

Infiltration by monocytes and/or macrophages

Faktor
Resiko
CKD
Kriteria Diagnosa
Epidemiologi
Cockroft-Gault MDRD
Differential Diagnosis
- Acute Kidney Injury
- Subacute Kidney Injury
- Acute on Chronic Kidney Disease
Treatment
- Manage Underlying Cause
- Dialysis
- Transplant
- Nutrient
Symptomatic
Hypertension:

- ACEI or ARB

Anemia:

- Iron Therapy or Transfusion

Dialysis
Prognosis