Professional Documents
Culture Documents
Togaviridae
Togaviridae
2. Rubivirus
Togavirus:
morphology
Toga: from Latin toga
“cloak” Envelope-
Capsid: 40-70 nm – Tightly bound to
diameter capsid
– Enveloped; Spherical – 2 peplomers: E1
– Icosahedral and E2 are
responsible for viral
nucleocapsid
specificity
– Comprised of
– Envelope acquired
multimers of 1 gene by budding
product
Togaviruses
Genome RNA
Cap An
nsP1 nsP2 nsP3 nsP4 Subgenomic 26S mRNA
cap An
C E3 E2 6K E1
Alphavirus: functions of nonstructural Proteins
Sindbis virus
– Common in Africa, Asia, Australia, Middle East,
Eastern Europe, Scandinavia and the Commonwealth
of Independent States
– transmitted by a mosquito vector
Alphavirus: clinical manifestations
Congenital Infection
(+) rubella infection in pregnant women
alter normal growth, mitosis and
chromosomal structure congenital
rubella syndrome (CRS)
Rubella
Clinical syndromes :
I.P. 12-21 days
Children : benign 3 day rash and
swollen glands
Adults : arthralgia, arthritis,
thrombocytopenia, postinfectious
encephalitis
Rubella Clinical Features
Incubation period 14 days (range 12-23 days)
Duration of
Immunity Lifelong
For others
– Explain theoretical risks
– Vaccinate