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BULLOUS DISORDER (4th Yr)
BULLOUS DISORDER (4th Yr)
DR MARIA MANSOOR
ASSISTANT PROFESSOR
DEPARTMENT OF DERMATOLOGY
DOW UNIVERSITY OF HEALTH SCIENCES
CLASSIFICATION
IMMUNOLOGICAL
NON IMMUNOLOGICAL
1. INFECTION 1. EPIDERRMAL
Bacterial PEMPHIGUS VULGARIS
Viral PEMPHIGUS VEGETANS
fungal PEMPHIGUS FOLIACEUS
2. TRAUMA
Burn
2. SUBEPIDERMAL
PEMPHIGOID
3. DRUGS
LINEAR IGA
Barbiturates
DERMATITIS
4. METABOLIC HERPETIFORMIS
Diabetes mellitus
5. GENETIC(MECHANOBULLOU)
Epidermolysis Bullosa
BULLOUS IMPETIGO
VIRAL INFECTION
BURN
STEVEN JOHNSON SYNDROME
MICROSCOPIC LEVEL OF BLISTERING
DERMOEPIDERMAL JUNCTION
1. EPIDERRMAL BLISTER
PEMPHIGUS VULGARIS
PEMPHIGUS VEGETANS
PEMPHIGUS FOLIACEUS
PEMPHIGUS VULGARIS
TARGET ANTIGEN
DESMOSOME
PEMPHIGUS VULGARIS
PEMPHIGUS VULGARIS
PEMPHIGUS VULGARIS
AGE MIDDLE AGE
SITE SCALP
FACE
FLEXURES
MUCOSA
BLISTER FLACCID
ANTIGEN DESMOSOME(DEMOGLEIN 3)
ANTIBODIES IgG
IMF INTERCELLULAR
SITE FLEXURES
MUCOSA
ANTIGEN DESMOSOME(DEMOGLEIN 1)
ANTIBODIES IgG
IMF INTERCELLULAR
PEMPHIGUS FOLIACEUS
PEMPHIGUS FOLIACEUS
SITE SCALP,FACE,CHEST,
UPPER BACK
ANTIGEN DESMOSOME(DEMOGLEIN1)
ANTIBODIES IgG
IMF INTERCELLULAR
2. SUBEPIDERMAL BLISTER
PEMPHIGOID
LINEAR IgA
DERMATITIS HERPETIFORMIS
PEMPHIGOID
TARGET ANTIGEN
HEMIDESMOSOME
TARGET ANTIGEN
BULLOUS PEMPHIGOID
AGE ELDERLY
SITE TRUNK,LIMB,
FLEXURES
MUCOSA
BLISTER TENSE
ANTIGEN HEMIDESMOSOME
ANTIBODIES IgG
IMF LINEAR BMZ
At higher power of the cleavage plane,
there are numerous eosinophils within
the papillary dermis, migrating into the
epidermis and blister cavity. The blister
cavity also contains fibrin. Mild spongiosis
is also noted. Immunofluorescence was
performed and confirmed the diagnosis
(not shown).
BULLOUS PEMPHIGOID
BULLOUS PEMPHIGOID
LINEAR IG A
TARGET ANTIGEN
ANTIGEN
HEMIDESMOSOME
LINEAR Ig A
BLISTER TENSE
ANTIGEN HEMIDESMOSOME
LAMINA LUCIDA
ANTIBODIES IgA
AGE YOUNG
ADULTS
BLISTER TENSE
ANTIGEN HEMIDESMOSOME
LAMINA LUCIDA
ANTIBODIES IgA
IMF granular
deposits
DERMATITIS HERPETIFORMIS
Histologic sections of skin show
several collections of
neutrophils, in clusters,
concentrated in the dermal
papillae. There is focal linear
deposition of neutrophils along
the dermal-epidermal junction,
with focal clefting.
DERMATITIS HERPETIFORMIS
DIMINISHED
BASAL CELL AND/OR
DEGENERATION ABNORMAL
EBS HEMIDESMOSOME
JEB
DIMINISHED
AND/OR ABNORMAL
ANCHORING
FIBRILS
EBD
EPIDERMOLYSIS BULLOSA SIMPLEX
PATHOGENESIS
BASAL CELL
DEGENERATION
EBS
EPIDERMOLYSIS BULLOSA SIMPLEX
JUNCTIONAL EPIDERMOLYSIS BULLOSA
PATHOGENESIS
DIMINISHED
AND/OR
ABNORMAL
HEMIDESMOSOME
JEB
JUNCTIONAL EPIDERMOLYSIS BULLOSA
EPIDERMOLYSIS BULLOSA DYSTROPHICA
PATHOGENESIS
DIMINISHED
AND/OR ABNORMAL
ANCHORING
FIBRILS
EBD
DYSTROPHIC EPIDERMOLYSIS BULLOSA