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Autoantibodies in Systemic Lupus Erythematosus Introduction and Historical Perspective
Autoantibodies in Systemic Lupus Erythematosus Introduction and Historical Perspective
Antinuclear antibodies
40-60 50-80 70-90 70-90 >95
Sensitivity
>95 Various
All ANAs
(by indirect IF)
- - - Diffuse- - 40-60
Target antigen DNA ANAAnti-dsDNA
type
Inflammatory Sjögren Limited Drug-induced
systemic SLE
myopathy syndrome Scleroderma LE
sclerosis
Core proteins of
- - - - - 20-30 All ANAsAnti-Sm
40-60 50-80 70-90 70-90 >95 >95 VarioussnRNPs
(by indirect IF)
- - - - - 40-60 DNA Anti-dsDNA
- - - - >95 50-70 Histones Anti-histone
Core proteins of
- - - - - 20-30 Anti-Sm
snRNPs
- - - - 10 - 15- >95 - 30-40
50-70 HistonessnRNPAnti-histoneU1 RNP
Histidine-tRNA
25 - - - - - Jo-1
ligase
- 60-90 - - - 10-15 RNPs SS-B (La)
Histidine-tRNA
25 - - - - - Jo-1
ligase