SICKLE CELL

ANEMIA
Presented by-
SHRUTI DHAGE
RITU PANDEY
VAISHNAVI BHAVAR PATIL
 OVERVIEW
Heamoglobin Types
Anemia Dignosis
What is sickle cell anemia? Prevelence
Causes Prevention
Hospital management Effect on pregnancy
Experimental treatment Conclusion
Sickle cell anemia v/s trait
 Types of Haemoglobin
STAGE IN DEVELOPMENT HEAMOGLOBIN STRUCTURE PROPORTION IN
NORMAL ADULT

EMBRYONIC GOWER 1 ζ2ε2 -

GOWER 2 α2ε2 -

PORTLAND 1 ζ2γ2 -

FOETAL F α2γ2 <1

ADULT A α2β2 97-98

A2 α2δ2 2-3
 WHAT IS ANEMIA?
• ANEMIA IS A DECREASE IN THE
TOTAL AMOUNT OF RBC OR Hb IN THE
BLOOD OR LOWER ABILITY TO CARRY
THE OXYGEN.
• IT AFFECTS 1/3 OF THE GLOBAL
POPULATION.
WHAT IS SICKLE CELL ANEMIA?
Normal Haemoglobin Cell

Sickle Cell Haemoglobin Cell

 The first documented
and recorded case of
Sickle cell in Western
medicine.
 “Peculiar elongated and
sickle shaped red blood
corpuscles in a case of
severe anemia”

IC K
HE RR
ES
JAM
 Stress Pregnancy
Being at high
CAUSES altitudes(low
oxygen tension)
(mountain
climbing, for Not having Concomitant
example) enough to medical
conditions.
drink
WATER.
Changes in
temperature, like
if you go from a
warm house into a
cold winter day
and you haven’t
Illness
bundled up
SIGNS
EFFECT OF SICKLE CELL
ANEMIA ON PREGNANCY
• MISCARRIAGE
• OPERATIVE TOLERANCE FOR
DELIVERY HAEMORRHAGE.
• PRE-TERM DELIVERY
• HEART FAILURE
• MATERNAL
MORTALITY
Hos
pital
man
age
men
t
Experimental treatments
SICKLE CELL ANEMIA V/S SICKLE CELL
TRAIT
• PEOPLE WHO HAVE SICKLE CELL ANEMIA ARE BORN
WITH IT; MEANS INHERITED , LIFE LONG CONDITION.
• THEY INHERIT TWO COPIES OF SICKLE CELL GENES
ONE FROM EACH PARENT.
• SICKLE CELL TRAIT IS DIFFERENT FROM SICKLE CELL
ANEMIA.
• PEOPLE WITH SICKLE CELL TRAIT DON’T HAVE THE
CONDITION BUT THEY HAVE ONE OF THE GENES THAT
CAUSE THE CONDITION.
• PEOPLE WITH SICKLE CELL ANEMIA AND SICKLE CELL
TRAIT CAN PASS THE GENE ON WHEN THEY HAVE
CHILDREN.
Sickle Cell Disease

Complications
• Complications include anemia , stroke ,
acute chest syndrome , pneumonia ,
organ damage.

Sickle Cell Awareness

Pass It On!
 Types of Sickle Cell Disease

Sickle Cell Anemia (SS)

Sickle Haemoglobin- C Disease (SC)
Sickle Beta-Plus Thalassemia
Sickle Hemoglobin-D Disease
Sickle Haemoglobin-
O Disease
PREVALENCE OF SICKLE CELL ANEMIA
Diagnosis
HOW CAN SICKLE CELL ANAEMIA BE
PREVENTED?
• YOU CAN’T PREVENT SICKLE CELL ANEMIA
BECAUSE IT’S AN INHERITED DISEASE.
HOWEVER, you can take steps to reduce its
complication.
• People who are at high risk for sickle cell anemia and
are planning to have children may want to consider
genetic counselling.
• A counsellor can help you understand your risk
 CONCLUSION
• SICKLE CELL DISEASE IS A MAJOR HEALTH PROBLEM
AND AN IMPORTANT RISK FACTOR FOR PERINATAL
MORBIDITY AND MORTALITY.
• MANAGEMENT SHOULD BE MULTIDISCIPLINARY.
• DESPITE ALL THE EFFECTS OF SICKLE CELL DISEASE
ON A PATIENT AND THE ATTENDENT PROBLEMS OF
A CO-EXISTING PREGNANCY, WITH ADEQUATE AND
SKILLED CARE OF THESE PATIENTS, A HAPPY
ENDING CAN REALISTICALLY STILL BE EXPECTED…..
•SICKLE CELL
ANEMIA DAY
19 JUNE
TH
SEPTEMBE
I WEAR BURGUNDY
FOR SOMEONE
WHO MEANS

THE WORLD
TO ME!