Strategy for Synthesizing of Benzo[a]carbazoles from

2‑Arylindoles and Acetophenones

:Supervised by
Assist. Prof.Dr. Ayad Kareem
Assist. Prof.Dr. Ayad mr rauuf

: Done by
M.S.C student
Mustafa habeeb
 introduction


A metal-free strategy for the synthesis of
.benzocarbazoles from 2-arylindoles and aryl ketones
Various 2-aryl-3-vinyl-indoles were generated in situ
through dehydrative condensation of aryl ketones and
indoles. These key intermediates could be selectively
converted into the corresponding benzo[a]carbazoles
via a direct cyclization process between two Csp2 −H
bonds. [1]


]2[
Carbazole and indole


]1[
Possible mechanism

]1[
 Importance of carbazole


Carbazoles are nitrogen-containing heterotricyclic 
motifs often found embedded in diverse natural
products and pharmaceuticals of varying complexity
and display a broad range of bioactivities such as
anticancer, antipsychotic, antimicrobial, antibiotic,
.anti-inflammatory, and antioxidative, to name a few
it is considered with indole as scaffold for preparation
of many other derivatives [4]
enghui Ni, Jing Tan, Wenqi Zhao, Huawen Huang, Fuhong ]1[
Xiao, and Guo-Jun Deng
,Organic Letters 2019 21 (10), 3687-3691
DOI: 10.1021/acs.orglett.9b01138

T. Aggarwal, S. . and A. K. Verma, Org. Biomol. ]2[

Chem., 2019, DOI: 10.1039/C9OB01381D

[3] https://https://en.wikipedia.org/wiki/Indole

hweta Singh, Ramesh Samineni, Srihari Pabbaraja, and ]4[

Goverdhan Mehta
Organic Letters 2019 21 (9), 3372-3376
DOI: 10.1021/acs.orglett.9b01111