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  • The Role of A Fas Ligand-Induced Cytokine Network in Metastasis

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    William Abdallah
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    Mesenchymal stem cells in the tumor microenvironment promote metastasis in cancers like breast cancer by secreting cytokines that bind to tumor cells. Fas ligand, a member of the tumor necrosis factor family, induces proliferation of mesenchymal stem cells. The study aimed to identify tumor types with Fas ligand-dependent mesenchymal stem cell proliferation and hypothesized that increased Fas ligand levels lead to mesenchymal stem cell proliferation and higher levels of pro-metastatic factors in the tumor microenvironment.

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    Mesenchymal stem cells in the tumor microenvironment promote metastasis in cancers like breast cancer by secreting cytokines that bind to tumor cells. Fas ligand, a member of the tumor necrosis factor family, induces proliferation of mesenchymal stem cells. The study aimed to identify tumor types with Fas ligand-dependent mesenchymal stem cell proliferation and hypothesized that increased Fas ligand levels lead to mesenchymal stem cell proliferation and higher levels of pro-metastatic factors in the tumor microenvironment.

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    24 views10 pages

    The Role of A Fas Ligand-Induced Cytokine Network in Metastasis

    Uploaded by

    William Abdallah
    Mesenchymal stem cells in the tumor microenvironment promote metastasis in cancers like breast cancer by secreting cytokines that bind to tumor cells. Fas ligand, a member of the tumor necrosis factor family, induces proliferation of mesenchymal stem cells. The study aimed to identify tumor types with Fas ligand-dependent mesenchymal stem cell proliferation and hypothesized that increased Fas ligand levels lead to mesenchymal stem cell proliferation and higher levels of pro-metastatic factors in the tumor microenvironment.

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    © All Rights Reserved
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    of 10

    The Role of a Fas Ligand-Induced Cytokine

    Network in Metastasis
    Meera Sayed
    Mesenchymal Stem Cells (MSCs) are part of the tumour microenvironment

    FIGURE????

    MSCs have been shown to promote metastasis in multiple cancer types like
    breast cancer.
    MSC induce metastasis by secreting different cytokines

     These cytokines bind to tumour cells and induce metastasis.


    FasL induces MSCs proliferation

     FasL which is known as CD95L, is


    a member of the tumor necrosis
    factor (TNF) family.

     Previous studies demonstrated that


    Fas ligand (FasL) induces
    proliferation of MSCs.
    Aim and Hypothesis
     Hypothesis: Increased FasL levels, lead to MSC proliferation and consequently to
    increased pro-metastatic factors, i.e. CCL2 in the tumour microenvironment.

     Aim: To identify tumour types with FasL-dependent MSC proliferation


    Methods and Materials
    Results

    Insignificant
    Significant
    Conclusions

     We have identified 7 tumours out of 19 in which they are FasL-dependent


    MSC proliferation.

     (When I finish the results, I will add the conclusion about CCL2, CCL5,CLL8
    and IL6).
    Acknowledgements
    Thank you for listening.
    Any Questions ?

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