Professional Documents
Culture Documents
Cardiac Drugs
Cardiac Drugs
Type of hyertension
Essential Hypertension= most common. About
90% of clients.
* Exact Origin unknown. Contributing Factors ‐
family history, hyperlipidemia, diabetes,
obesity, aging, stress, excessive ETOH &
smoking.
Secondary Hypertension is about 10% , related
to endocrine or renal disorders
Stages of hypertension
Antihypertensives are a class of drugs that
are used to treat hypertension (high blood
pressure).
Classification (ABCD)
Angiotensin converting Enzyme (ACE) inhibitor
Angiotensin-II receptor blocker
Alpha-1 receptor blocker
Alpha-2 receptor agonist
Beta adrenoceptor blocker
Calcium channel blocker
Diuretics
Angiotensin converting
Enzyme (ACE) inhibitor
Angiotensin converting
Enzyme (ACE) inhibitor (--pril)
•e.g., Ramipril, Captopril, Enalpril etc
•Inhibits ACE enzyme
•Blocks the synthesis of angiotensin-II
-Causes vasoconstriction
-Reduces aldosterone: reduced Na+ and
water retention
ACE inhibitor
Among the three zinc binding group, sulfhydryl
group is superior, but they form disulfide which
may result in shorter duration of action.
Lisinopril
Lysine analogue of Enalpril
Fosinopril
Synthesis of Captopril
Angiotensin II receptor blocker
Angiotensin II receptor blocker (-sartan)
Losartan,valsartan, irbesartan, olmesartan,
candesartan, fimasartan and azilsartan
They block the activation of Angiotensin receptors,
preventing the binding of angiotensin II.
Dec. Activity of angiotensin II, dec. blood pressure
Dec activity of angiotensin II, dec. aldosterone
secretion, dec. Na+ ion retention
Used primarily for the treatment
of hypertension where the patient is intolerant
of ACE inhibitor therapy
SE: Headache, nausea, dizziness, Back pain
Imidazole ring
Losartan Valsartan
• 2. Mechanism of Action
Alpha 2 receptor agonist
Methyldopa
Clonidine
Guanfacine
Structural comparison between the neurotransmitter
norepinephrine and the drug clonidine. Both drugs bind
to alpha-2 adrenergic receptors.
Loop diuertics
Thiazide diuretics
Potassium sparing agents
https://slideplayer.com/slide/10587411/
Loop Diuretics/ High Ceiling Diuretics
• TAL responsible for 35% reabsorption of filtered
sodium.
• Therefore loop diuretics are highly efficacious or
“High Ceiling Diuretics”
• The Na+ —K+ —2Cl– symport and sodium
pump together generate a positive lumen
potential that drives the reabsorption of Ca++
and Mg++,Therefore, Ca++ and Mg++ inhibited
as well.
5-Sulfamoyl-2-aminobenzoic acid
derivatives
Furosemide
4-Chloro-N-fufuryl-5-sulphamoylanthracillic acid
5-sulfamoyl-3-aminobenzoic acid
derivatives.
Bumetanide
3-butylamino-4-phenoxy-5-sulphamoylbenzoic acid
SAR
https://www.slideshare.net/manassehsallau/ft
hg-presentation
https://slideplayer.com/slide/10587411/
Discovery and development of statins
https://en.wikipedia.org/wiki/Discovery_and_d
evelopment_of_statins