Fermenter: Types

• (Continuous) Stirred Tank Bioreactors

• Airlift Fermenter
• Bubble Column Fermenter
• Fluidized Bed Bioreactors
(Continuous) Stirred Tank Bioreactors
• Functions: homogenization, suspension of solids,
dispersion of gas-liquid mixtures, aeration of liquid
and heat exchange.
• The Stirred tank reactor is provided with a baffle
and a rotating stirrer is attached either at the top
or at the bottom of the bioreactor.
• The typical decision variables are: type, size,
location and the number of impellers; sparger size
and location.
• These determine the hydrodynamic pattern in the
reactor, which in turn influence mixing times, mass
and heat transfer coefficients, shear rates etc. 
• In Continuous Stirred Tank Bioreactor, the contents of the vessel will not vary, the steady state is
maintained by continuous supply of nutrition or microorganism and by continuous removal of the
product or waste.
• Widely used in fermentation industry, waste water treatment etc.
• Important point in this reactor is to maintain the autocatalytic nature of microbiological reactions.
• This is because the presence of one of the products, additional micro-organisms, enhances the
overall rate of reaction.
• In the absence of micro-organisms no reaction can take place.
• Therefore, it is essential to retain at least a portion within the fermentor. It follows that if the flow
rate is raised to a high value, then all the micro-organisms will be swept from the fermentor, and
the conversion will cease. This phenomenon is commonly known as 'Wash-out'. if micro-organisms
are fed to the fermentor simultaneously with the substrate feed, the problems associated with
wash-out are abated, and the reaction proceeds normally.
• Advantages of Stirred Tank Bioreactor
• Continuous operation
• Good temperature control
• Easily adapts to two phase runs
• Good control
• Simplicity of construction
• Low operating (labor) cost
• Easy to clean
Airlift Fermenter
• In airlift fermenter the liquid culture volume of the vessel is divided into two interconnected zones by means of a baffle or
draft tube.
• Air or other gas are sparged through one zone, and this sparged zone is known as the riser.
• The other zone that receives no gas is called down-comer.
• The bulk density of the gas-liquid dispersion in the gas-sparged riser tends to be lower than the bulk density in the down-
comer.
• Consequently the dispersion flows up in the riser zone and down-flow occurs in the down-comer.
• Advantages:
• Energy efficient
• Suitable for animal cell cultures
• More effective in suspending solids
Bubble column Fermenter
• Bubble column fermenter a simple cylindrical glass
chamber with an aspect (height to diameter) ratio of 4-6.
• Gas is sparged at the base of the column through
perforated pipes, perforated plates, or sintered glass or
metal micro-porous spargers.
• O2 transfer, mixing and other performance factors are
influenced mainly by the gas flow rate and the properties
of the fluid.
• Internal devices such as horizontal perforated
plates,vertical baffles and corrugated sheet packing,s
may be placed in the vessel to improve mass transfer and
modify the basic design
Fluidized bed bioreactor
•  Fluidized bed bioreactor is comparable to bubble
column bioreactor except the top position is
expanded to reduce the velocity of the fluid. 
• The design of the fluidized bioreactors (expanded
top and narrow reaction column) is such that the
solids are retained in the reactor while the liquid
flows out.
• These bioreactors are suitable for use to carry
out reactions involving fluid suspended
biocatalysts such as immobilized enzymes,
immobilized cells, and microbial flocs