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    The Role of Advanced Computing Techniques in FISH

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    ManoMansoor
    This document discusses how advanced computing techniques such as artificial intelligence and machine learning can help optimize and automate fluorescent in situ hybridization (FISH) analysis. It describes how FISH is used to detect chromosomal abnormalities but current techniques are manual and labor-intensive. The document proposes that AI models including machine learning and deep learning could computationally optimize FISH assay conditions, design more efficient probes, and enable automated, high-throughput FISH image processing and pattern recognition to reduce the workload of manual analysis.

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    The Role of Advanced Computing Techniques in FISH

    Uploaded by

    ManoMansoor
    36 views10 pages
    This document discusses how advanced computing techniques such as artificial intelligence and machine learning can help optimize and automate fluorescent in situ hybridization (FISH) analysis. It describes how FISH is used to detect chromosomal abnormalities but current techniques are manual and labor-intensive. The document proposes that AI models including machine learning and deep learning could computationally optimize FISH assay conditions, design more efficient probes, and enable automated, high-throughput FISH image processing and pattern recognition to reduce the workload of manual analysis.

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    This document discusses how advanced computing techniques such as artificial intelligence and machine learning can help optimize and automate fluorescent in situ hybridization (FISH) analysis. It describes how FISH is used to detect chromosomal abnormalities but current techniques are manual and labor-intensive. The document proposes that AI models including machine learning and deep learning could computationally optimize FISH assay conditions, design more efficient probes, and enable automated, high-throughput FISH image processing and pattern recognition to reduce the workload of manual analysis.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pptx, pdf, or txt
    36 views10 pages

    The Role of Advanced Computing Techniques in FISH

    Uploaded by

    ManoMansoor
    This document discusses how advanced computing techniques such as artificial intelligence and machine learning can help optimize and automate fluorescent in situ hybridization (FISH) analysis. It describes how FISH is used to detect chromosomal abnormalities but current techniques are manual and labor-intensive. The document proposes that AI models including machine learning and deep learning could computationally optimize FISH assay conditions, design more efficient probes, and enable automated, high-throughput FISH image processing and pattern recognition to reduce the workload of manual analysis.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pptx, pdf, or txt
    of 10

    The Role of Advanced

    Computing Techniques in
    FISH Analysis

    Marrium Mansoor
    Overview
    Fluorescent in situ Hybridization

    Artificial Intelligence and AI Models

    Optimization of FISH Assays

    Automated FISH Analysis


    Fluorescent in situ Hybridization (FISH)
    • A molecular cytogenetic
    technique that can detect
    chromosomal abnormalities
    • High specificity
    • High resolution
    • Can be performed on both
    interphase and metaphase cells
    Fluorescent Microscopy

    Taken from Dewald et al. (1998)


    Artificial Intelligence (AI)

    Supervised Unsupervised Reinforcement


    Learning Learning Learning
    AI Models

    Machine Deep
    Learning Learning
    How can we use AI
    in FISH techniques?
    Optimization of FISH Assays
    • Computationally predict optimal hybridization temperatures for
    probes.
    • Model and design more efficient probes by optimizing:
    • Probe concentration, sequence, length and type
    • Ionic strength
    • Rate enhancing agents
    • Volume exclusion agents
    • Destabilizing agents
    Automated FISH Analytics

    Biological High-
    Image
    pattern Throughput
    processing
    recognition Imaging (HTI)

    Machine
    Deep learning
    learning
    Thank you!

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