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Hyperthyroidism
Hyperthyroidism
HYPERTHYROIDISM
Achmad Harun,MD
Medical Faculty of Indonesia Muslim University
SIGNS AND SYMPTOMS
Skin: Increased Sweating and heat intolerance, onycholysis,
hyperpigmentation, pruritus and thinning of the hair.
Diffuse goiter
If TBG goes up-T4 and T3 would go up. If TBG goes down-T4 and
T3 would go down.
GENERAL RULE
High T4 and T3 early on- High T4 and T3 with low Initially eu, hyper- or hypo,
later low T4 and T3. Low TSH initially, then Low eventually hypothyroid.
RAIU RAIU, low T4 and T3. Low RAIU.
Anti-thyroglobulin antibodies Anti-thyroglobulin antibodies Anti-thyroglobulin antibodies
are usually elevated. TPO may or may not be elevated. are present in 85% of
antibodies usually normal. TPO elevated in 75% of cases.
cases.
TPO in 95% of cases.
Aspirin/Steroids Beta-blockers if needed Levothyroxine if needed
INDICATIONS FOR SURGERY
Patients with very large goiters
Pregnant women who are allergic to antithyroid drugs and/or are tolerating
hyperthyroidism poorly
Case 1
A 27-year-old woman is evaluated for palpitations and heat intolerance that develop
3 months after a successful pregnancy. She is breastfeeding. The patient's older
sister has Graves' disease, but the patient herself has no history of thyroid disease.
On physical examination, the blood pressure is 128/70 mm Hg, and the pulse rate is
104/min. Eye examination reveals stare and lid lag, but no proptosis. The thyroid
gland is moderately enlarged and nontender. She has moist palms and brisk deep
tendon reflexes. Serum free T4 is 2.7 ng/dL (34.2 pmol/L), free T3 46.22 ng/dL (7.1
pmol/L), and thyroid-stimulating hormone (TSH) is undetectable. Which one of the
following is the most appropriate next step in this patient's management?
A- Amiodarone-induced thyroiditis
B- Iodine-induced hyperthyroidism
C- Expected changes in euthyroid patients taking amiodarone
D- Spurious laboratory results caused by amiodarone
E- Euthyroid sick syndrome
Case 4
A 24-year-old woman is evaluated for palpitations and sweating that began 4
weeks after she delivered her first child 8 weeks ago. She has had
occasional loose stools. Otherwise, she has felt generally well. She nursed
her baby for 6 weeks but decided to stop 2 weeks ago. Her family history is
unremarkable. She is taking multivitamins but no other supplements. On
physical examination, the blood pressure is 110/60 mm Hg, pulse rate
92/min, and BMI 23.7. The thyroid gland is normal size, slightly firm in
consistency, and nontender. Thyroid-stimulating hormone<0.01µU/mL, free
T4=3.4ng/dL, total T3=315ng/dL, radioiodine uptake<1%. Thyroid scan not
visualized. Which of the following is the most appropriate therapy for this
patient?
A- Graves disease.
B- Subacute thyroiditis.
C- Chronic lymphocytic thyroiditis
D- Factitious hyperthyroidism
E- Hashimoto’s thyroiditis.
Case 7
A 33 year old female gave birth to a healthy child 6 weeks ago. She
complains of tremors and anxiety. T4 is elevated while TSH is low normal.
In addition to prescribing beta-blockers, which of the following would you
order to confirm your diagnosis?
A- Lugol iodine
B- Radioactive iodine
C- RAU uptake
D- Observation
Case 8
A 32 year old, 4 months post-partum nurse comes to you for depression.
O/E thyroid is enlarged but painless to palpation. Blood tests reveal high T3
and low TSH. What is your next step in the management of this patient?
A- Free T4
B- RAI uptake
C- A trial of propylthiouracil
D- Propranolol
E- Observation
Case 9
2 months later she comes back with continued symptoms of depression.
The previously ordered RAIU was low. Blood tests now reveal low T3 and
high TSH. What is your next step in the management of this patient?