I N D U S T R I A L T R A I N I N G AT

BENHAM PHARMACEUTICAL
LT D .
• Name : Md Rabbi Khan
• Matric : A17KM4005
• LI Supervisor Name : prof. Dr. Hasbullah
 INTRODUCTION
Company Background

• BENHAM is a fast-growing pharmaceutical company in Bangladesh. They set their objective is as a

quality-driven pharmaceutical company that continues to grow with each passing day. Excellence in
Quality, patient’s health and safety is on top priority and we are cared to cure as well. BENHAM starts its
operation with a handful of highly skilled and dedicated professionals guided by an able leadership. Proper
strategic planning, technical excellence, swift and timely decisions helped them achieve their objectives
leading to much faster growth.

• Introduced in 2012, the signifies Blue color of Sky. The logo radiates a sense of youthfulness & whole
happiness.

• As a newcomer in pharmaceutical industry in Bangladesh, they are committed to promote economic growth
in a safe, secure and responsible manner. They, promote a positive and open environment across our
businesses, supported by effective communication between management, employees and health
professionals. Their management team and employees know that the sustainable long-term future of their
business’s rests on their track record on Environment, Health and Safety.
 C O M PA N Y O V E R V I E W

• Departments • I visited
Ware house  Engineering department
Engineering department
 Quality control
Marketing
 production
Planning and procurement department
Quality control
production
PORFILE ABOUT BENHAM
P H A R M A C E U T I C A L LT D

Company Name: Benham Pharmaceutical

Ltd.
Factory Location: Aicha Nwaddah,
Rajashon Road,Savar
Head Office: House-60/1, Road- 12/A,
Dhanmondi,Dhaka-1209
Corporate Setup: Private Limited Company.
Manufacturing areas: 122000 sft.
Established Year: 2012
POPULAR PRODUCTS OF
B E N H A M P H A R M A C E U T I C A L LT D
P R O D U C T I O N D E PA RT M E N T

LIQUID
SECTIO
N

DRY PRODUCTIO
TABLET
SYRUP N
SECTIO
SECTIO DEPARTME
N
N NT

CAPSUL
E
SECTIO
N
P R O D U C T I O N D E PA RT M E N T

Tablets are solid dosage forms consisting of active

ingredient(s) and suitable pharmaceutical excipients.
They may vary in size, shape, weight,
hardness, thickness, disintegration
and dissolution characteristics.
P R O D U C T I O N D E PA RT M E N T

• The Tablet section performed the following steps to manufacture a complete tablet dosage form.

dispensing granulation compression

coating

packaging
P R O D U C T I O N D E PA RT M E N T

1. Dispensing
• It is one of the most important and the first step to prepare any type of dosage form.

• Purpose: -

• To evaluate the correct quantity of drug and excipients .

• To prepare a unit dosage form.

• To obtain standard dissolution, disintegration and other test done.

P R O D U C T I O N D E PA RT M E N T

1. Granulation
• Granulation is the process where the granules are
prepared from the powders.

Types:
A. Wet granulation
B. Dry granulation
C. Direct compression
P R O D U C T I O N D E PA RT M E N T

• A. wet granulation
• Steps :

Granulating in
rapid mixing Drying in fluid
Weighing multi milling
granulator(RMG bed dryer(FBD)
)

Lubrication (in
screening compression
blender)
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RMG FBD DOUBLE CONE BLENDER

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FLUID BED PROCESSOR

P R O D U C T I O N D E PA RT M E N T

• B. dry granulation
• Steps: Requisition of raw materials

Weighing/Dispensing

Compression into slugs or roll compaction

Milling and screening of slugs

Lubrication/Blending
P R O D U C T I O N D E PA RT M E N T

• C. direct compression
• Steps: Weighing Mixing & Mixing compressio Tablet is
of the Sieving with lobe n prepared
ingredients according
to desired
mesh size
P R O D U C T I O N D E PA RT M E N T

1. Compression:
• Compression is the process to prepare tablet by compacting the masses.

• Purpose:
• For the preparation of tablet
• To prepare accurate uniformity and tablet dosage form.
P R O D U C T I O N D E PA RT M E N T

• TABLET COMPRESSION MACHINE(JAGUAR):

P R O D U C T I O N D E PA RT M E N T

• Compression Process :

Tablet is Checking size,

prepared by shape and
Weighting of Put the materials compression hardness,
Filling of dies Ejection
granules into the hopper between the thickness, D.T,
rotating area of Friability of the
punch and dies tablet.
P R O D U C T I O N D E PA RT M E N T

1. Coating
• It is the process to put an outer surface or coat on
tablet. We observed the coating of “Ranitidine” tablet.

• Purpose:
• Protect the ingredients from the environment
• Produce prolonged duration of action
• Increase pharmaceutical elegance
• To mask the bitter and unpleasant taste
P R O D U C T I O N D E PA RT M E N T

• Coating Process :

Temp. of pan,
Solution is
inlet & outlet Solution is
Tablets to be sprayed onto
air pressure, connected to
coated is taken the tablets by Coating
RPM of pan machine by
in coating pan spray guns of
etc are tubes
the machine.
adjusted
P R O D U C T I O N D E PA RT M E N T

Coating Machine :
P R O D U C T I O N D E PA RT M E N T

5. Packaging
Packaging is the last step of tablet section. It is the process that protects
product from environment (dust, foreign particles etc.) during distribution,
storage, sale and use.

• Purpose
 To provide convenience to user.
 To ensure satisfactory sealing.
P R O D U C T I O N D E PA RT M E N T

• Blister packaging machine

P R O D U C T I O N D E PA RT M E N T

Process of Blister Packaging:

Tablet or capsules
Formation of
Heating (temp. are filled into the
PVC sheet pocket by air
125 to 145 C) pocket
pressure
automatically

Sealing with labeling & Batch

Auto feed checker Cutting
aluminum top foil Printing
P R O D U C T I O N D E PA RT M E N T

CAPSULE SECTION:
Capsules are solid preparations with hard or soft shell of various shapes and
capacities, usually containing a single dose of active substance(s).They are
intended for oral administration.
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Types of capsules:
1.HARD gelatine capsule (double piece) 2.Soft gelatine capsule (single piece)
P R O D U C T I O N D E PA RT M E N T

Manufacturing process of Hard Capsule in Automatic machine:

Caps and bodies powder are

Empty capsule are separatedby the automatically Enclosing of cap
Shells in hopper
shell force created by filled in body of and body
vacuumpressure shell

Packaging Inspection Finishing Ejection

P R O D U C T I O N D E PA RT M E N T

Manufacturing process of Hard Capsule: Manual

Capsule shells
are set into Body and cap
Plate set into Fill the body Attached
the plate separated by Capsules
the hand filler with materials body and cap
through in scissor
setter
P R O D U C T I O N D E PA RT M E N T

C. DRY SYRUP SECTION

This is a powder dosage form of oral drug used because the drug is unstable in solution. It
must be reconstituted before use. It is mainly sugar based preparation. We observed the
preparation of Quinter dry syrup (BEN-KOP).

Purpose:
 For the easy administration of drugs
 To obtain the effectively of the drug completely after reconstitution
 P R O D U C T I O N D E PA RT M E N T

Process:
Milling and drying of sweetener
 
 
Transfer to a drum blender
 
 

  Sieving and addition of active ingredients and other excipients Proper mixing

Proper mixing

Bottle filling and sealing

P R O D U C T I O N D E PA RT M E N T

D. LIQUID SECTION:

A drug administer in solution is immediately available for absorption and in most

case is more rapidly and efficiently absorbed than the same amount of drug
administered in tablet and capsules.
In Liquid processing unit two types of liquid dosage form are manufactured. This are-
1. Syrup
2. Suspension
P R O D U C T I O N D E PA RT M E N T

• Manufacturing Process of liquids:

Transfer of the Filling, Flushing of

Weighing of active Excipients are Passing through a solution to the Nitrogen (N2) &
Active is added to
ingredients along mixed in a Charge Pump to the filling vessel Sealing of Bottles
the vessel & mixed
with excipients. vessel storage vessel through 0.5µ containing oral
Cartridge filter liquid.
P R O D U C T I O N D E PA R T M E N T

• Filling & Sealing Machine: Pharma lab

P R O D U C T I O N D E PA RT M E N T

Process of Liquid Filling:

Transfer of Prepared liquid preparation into the filling machine from the processing vat using
transfer pump.
 
Set the machine according to filling volume

 
Filling of bottles
 
Sealing of bottle using sealing machine

Labeling & Packaging of bottles

P R O D U C T I O N D E PA RT M E N T

Quality Assurance is a wide-ranging concept which covers all matters

which individually or collectively influence the quality of a product.
Quality
Assurance
Department

Quality In Process
Documentation Microbiology
Control Control
P R O D U C T I O N D E PA RT M E N T

Every production biased company has a warehouse. There are two

types of warehouse. Finished product store is one of them.
THANK YOU