Professional Documents
Culture Documents
Immunity To Specific Infection
Immunity To Specific Infection
SEMESTER-7 BLOK-VI
MODUL-3 PENYAKIT INFEKSI TROPIS
FK UNSRAT
2011
Overview:
Immunity to Microbes
IMMUNITY TO MICROBES
(A BRIEF OVERVIEW)
• Functions:
– block infection
– eliminate the microbes
– neutralize their toxins
ADAPTIVE Immune Response to Extracellular Bacteria
(antibody and T-helper response)
Extracellular bacteria Examples of human diseases Mechanisms of pathogenicity
Staphylococcus aureus Skin and soft tissue infections, Skin infection; acute inflammation
lung abscess; induced by toxins (cell death by
systemic: toxic shock syndrome, pore-forming toxins)
food poisoning Systemic: enterotoxin
‘superantigen’ - induced cytokine
production by T cells causing skin
necrosis, shock, diarrhea
• Initially
neutrophils and later macrophages
→ ingest and attempt to destroy these microbes