bioavailability

bioavailability

Availability of active drug

defn…
.it is a measure of the fraction (f) of
administerd dose of a drug that reaches
the systemic circulation in the unchanged
form
 i/v----->bioavailability is 100 %

oral-less

s.c-- less

i/m-- less
So—i/v.>i/m>s.c>oral
Half life---t/2—
it is time required for 50% of
ompletion of process.
usually a drug is removed from
hebody not at a constant rate but at a rate
which is proportional to its plasma
oncentration.
graph

• Grph of concn.. Against time is

straight line,(log curve). As
concn.. Increased –excrn.. Is
also increased
Types

• Half life are of three types.

• plasma half life

• -elimination half life

• --biological half ife

Plasm half life

•It is time in which

the plasma concn…
of the drug is fall by
50%
Elimination half life

•Time taken to
excrete 50% of
quantity of drug
Biological half life

•It is time taken for

50% of
disappearance of
effect of drug
e.g.

• Vit-D—plasma half life is

short.but its biological h. l is
two weeks.

• Reserpine– when given by i/v –

h.l. is few hours, but its effect
last for 3 weeks
uses

• 1- drug with short half life need

frequent administration.

• 2-drug with long H.. L.. Ned less

dose needed.