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Extremophiles: Life On The Edge
Extremophiles: Life On The Edge
Obsidian Pool,
Yellowstone National
Park
Hydrothermal Vents
Psychrophiles
Chemical Extremes
Acidophiles - Acidic
– Again thermal vents and some hot springs
Alkaliphiles - Alkaline
– Soda lakes in Africa and western U.S.
Halophiles - Highly Salty
– Natural salt lakes and manmade pools
– Sometimes occurs with extreme alkalinity
Acidophiles
pH 0-1 of waters
at Iron Mountain
Alkaliphile
solar salterns
Owens Lake,
Great Salt Lake
coastal splash zones
Dead Sea
Survival
Temperature extremes
– Every part of microbe must function at extreme
» “Tough” enzymes for Thermophiles
» “Efficient” enzymes for Psychrophiles
– Many enzymes from these microbes are
interesting
Enzyme
Product B
Substrate A Product C
What are enzymes?
Activation energy
– Enzymes allow reactions with lower energy
Without Enzyme
With Enzyme
Energy
Time
What are enzymes?
Enzymes are just a protein
– They can be destroyed by
» Heat, acid, base
– They can be inhibited by
» Cold, salt
Try doing this with an egg white or milk
– Protein is a major component of both
Practical Applications
Extremozymes
» Enzyme from Extremophile
Industry & Medicine
What if you want an enzyme to work
– In a hot factory?
– Tank of cold solution?
– Acidic pond?
– Sewage (ammonia)?
– Highly salty solution?
One solution
Pay a genetic engineer to design a “super”
enzymes...
– Heat resistant enzymes
– Survive low temperatures
– Able to resist acid, alkali and/or salt
This could take years and lots of money
Extremophiles got there first
Nature has already given us the solutions to
these problems
– Extremophiles have the enzymes that work in
extreme conditions