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  • In Vitro Drug Interactions: Drugs Interactant Result

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    Christina
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    This document summarizes several in vitro drug interactions. It shows that ceftriaxone sodium forms a precipitate when mixed with lactated Ringer's solution due to calcium in Ringer's solution. Daptomycin forms a precipitate when mixed with dextrose solution but is compatible with 0.9% saline and lactated Ringer's solution. Piperacillin-tazobactam forms particles or changes color when mixed with select drugs. Cefepime degradation can increase up to 25% when mixed with theophylline. The document warns that ceftriaxone should not be used in neonates due to the risk of fatal precipitates.

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    Farmakoterapi Terapan

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    In Vitro drug interactions

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    This document summarizes several in vitro drug interactions. It shows that ceftriaxone sodium forms a precipitate when mixed with lactated Ringer's solution due to calcium in Ringer's solution. Daptomycin forms a precipitate when mixed with dextrose solution but is compatible with 0.9% saline and lactated Ringer's solution. Piperacillin-tazobactam forms particles or changes color when mixed with select drugs. Cefepime degradation can increase up to 25% when mixed with theophylline. The document warns that ceftriaxone should not be used in neonates due to the risk of fatal precipitates.

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    22 views3 pages

    In Vitro Drug Interactions: Drugs Interactant Result

    Uploaded by

    Christina
    This document summarizes several in vitro drug interactions. It shows that ceftriaxone sodium forms a precipitate when mixed with lactated Ringer's solution due to calcium in Ringer's solution. Daptomycin forms a precipitate when mixed with dextrose solution but is compatible with 0.9% saline and lactated Ringer's solution. Piperacillin-tazobactam forms particles or changes color when mixed with select drugs. Cefepime degradation can increase up to 25% when mixed with theophylline. The document warns that ceftriaxone should not be used in neonates due to the risk of fatal precipitates.

    Copyright:

    © All Rights Reserved
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    In Vitro drug interactions

    Drugs Interactant Result


    Ceftriaxone sodium Lactated Ringer's solution Ca-Ceftriaxone precipitate
    Daptomycin Dextrose solution Daptomycin precipitate
    0.9% saline solution
    Daptomycin Compatible
    Lactated Ringer's solution
    Piperacillin-tazobactam Acyclovir Particle formation
    Amphotericin B Flocculent
    Mitomycin Blue colour
    Theophylline Cefepime Cefepime degrades up to 25%

    David W. Newton (2009) Am J Health-System Pharm. 66(4):348-357


    Thilo Bertsche et al (2008) Am J Health-Syst Pharm.  65(19):1834-1840
    Ceftriaxone-calcium precipitates in lungs &
    kidneys of neonates (FDA warning)

    • Neonates with hyperbilirubinemia, especially premature


    infants, should not be treated with ceftriaxone.
    • In vitro studies : ceftriaxone can displace bilirubin from
    binding to serum albumin, potentially leading to
    bilirubin encephalopathy.
    • Fatal reactions : ceftriaxone-calcium precipitates in the
    lungs and kidneys of neonates.
    • Do not mix Ceftriaxone with calcium-containing
    products (Ringer's or Hartmann's solution).

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