KULIAH PAKAR

SKENARIO 1
LOO HARIYANTO RAHARJO
Homeostas
is of blood
glucose
• Glucose cannot passively move across the cell
membrane to enter the cells.
• The polar nature of glucose hinders its
movement across the predominantly non-
polar lipid bilayer.
• Two kinds of transport mechanisms:
• the facilitated transport,
• the secondary active transport
• Secondary active transport is the mechanism
of sodium-glucose cotransport across the
membranous barrier, against a concentration
gradient of glucose (i.e. from lower glucose
concentration to a relatively higher
concentration)→movement of glucose from
lumen of intestine into the intestinal mucosal
cells , Another type of such Na+/glucose co-
transporter (called SGLT-1) is known to operate
in renal tubules.
Glycolysis
• Under normal circumstances, 100%
of the glucose that is filtered is
reabsorbed.
• Glucose reabsorption involves
transport proteins that require
specific binding.
• In a diabetic that has hyperglycemia,
the filtered load of glucose (amount
of glucose filtered) can exceed the
capacity of the kidney tubules to
reabsorb glucose, because the
transport proteins become
saturated.
• The result is glucose in the urine.
Glucose is a solute that draws water
into the urine by osmosis.
• Thus, hyperglycemia causes a
diabetic to produce a high volume
of glucose-containing urine