IVERMECTIN:

 It is the drug of choice which

treats Onchoceriasis (river
blindness) caused by
Onchorea volvulus.
 It is effective against scabies.
MECHANISM OF ACTION:
Ivermectin
Targets
GABA receptors of parasite

Chloride ion influx

enhanced Hyper

polarization occurs
CONTRA INDICATIONS:

 Patients with MENINGITIS

 Pregnancy

 The killing of microfilaria can results

in Mazotti like reaction

TREMATODES:
 These are the leaf shaped flatworms.
 These are called as flukes.

 They are generally characterized by the

tissues they infect.

Eg: Liver, lung, intestinal or blood
flukes.
DRUGS USED FOR THE
TREATMENT OF TREMATODES:

PRAZIQUANTEL:

 Trematode infections are generally

treated with praziquantel.
 It is a drug of choice to treat

Schistosomiasis & cestode

infections like Cysticercosis.
MECHANISM OF ACTION:
 Permeability of the cell
membrane to calcium ion
is increased.
 This leads to contraction and

so paralysis of the parasite

occurs.