Professional Documents
Culture Documents
Acute Renal Failure: Dr. S.Raghav MD
Acute Renal Failure: Dr. S.Raghav MD
Acute Renal Failure: Dr. S.Raghav MD
DR. S.RAGHAV MD
DEFINITION
ABRUPT DECREASE IN RENAL
FUNCTION RESULTING IN THE
ACCUMULATION OF
NITROGENOUS COMPOUNDS
SUCH AS UREA AND
CREATININE
Acute Renal Failure
Rapid decline in the GFR over days to
weeks.
Cr increases by >0.5 mg/dL
GFR <10mL/min, or <25% of normal
Hyperkalemia
Nausea/Vomiting
HTN
Pulmonary edema
Ascites
Asterixis
Encephalopathy
Causes of ARF in hospitalized
patients
45% ATN
Ischemia, Nephrotoxins
21% Prerenal
CHF, volume depletion, sepsis
10% Urinary obstruction
4% Glomerulonephritis or vasculitis
2% AIN
1% Atheroemboli
ARF: Focused History
Nausea? Vomiting? Diarrhea?
Hx of heart disease, liver disease, previous renal
disease, kidney stones, BPH?
Any recent illnesses?
Any edema, change in
urination?
Any new medications?
Any recent radiology studies?
Rashes?
Physical Exam
Volume Status
» Mucus membranes, orthostatics
Cardiovascular
» JVD, rubs
Pulmonary
» Decreased breath sounds
» Rales
Rash (Allergic interstitial nephritis)
Large prostate
Extremities (Skin turgor, Edema)
Acute vs Chronic Renal
Failure
History
» Known Chronic
» Recent Toxic Exposure
» Recent Hypoxic Insult
» Recent Trauma
» Known Diseases Associated with ARF
» Prev. Abnormal Lab Results Suggesting
Chronic
Acute vs Chronic Renal
Failure
PRE-RENAL 55-60%
RENAL 35-40%
PRE-RENAL ACUTE RENAL
FAILURE
VASCULAR DISEASE
» VASCULITIS (SLE, POLYARTERITIS
ETC.)
» SCLERODERMA
» THROMBOEMBOLIC DISEASE
» MALIGNANT HYPERTENSION
RENAL--ACUTE RENAL
FAILURE
GLOMERULAR DISEASE
» ACUTE GLOMERULONEPHRITIS
– POST INFECTIOUS GN
– CRESCENTIC GN
ANCA POSITIVE DISEASES
– GOODPASTURE’S DIS.
ANTI- GLOMERULAR BASEMENT
ANTIBODY
Postinfectious Proliferative
Glomerulonephritis
Usually after strep infxn of upper respiratory
tract or skin – 8-14 day latent period
» Can also occur in subacute bacterial endocarditis,
visceral abscesses, osteomyelitis, bacterial sepsis
Hematuria, HTN, edema, proteinuria
Positive antistreptolysin O titer (90% upper
respiratory and 50% skin)
Treatment is supportive
» Screen family members with throat culture and treat
with antibiotics if necessary
RBC CAST
ACUTE INTERSTITIAL NEPHRITIS
DRUG INDUCED
PENICILLINS NSAID
SULFONAMIDES (FENOPROFEN)
CEPHALOSPORIN ALLOPURINOL
RIFAMPIN ( 2ND PHENYTOIN
TIME) THIAZIDES
QUINOLONES FUROSEMIDE
CIMETIDINE
Acute Interstitial Nephritis
Fever
Rash
Eosinophilia
Pyuria
WBC Casts
AIN Management
MYOBLOBINURIA (RHABDOMYOLYSIS)
ENDOTOXEMIA
RENAL-- ACUTE RENAL FAILURE
HISTORY
PHYSICAL EXAMINATION
ASSMENT OF URINE VOLUME
URINE ANALYSIS
BLOOD CHEMISTRY
BLOOD AND URINE INDICES
RADIOLOGIC STUDIES
Treatment of ARF
Hyperkalemia
DISORDERS
~hyperkalemia
SEVERE REFRACTORY ACIDOSIS
INDICATIONS FOR DIALYSIS IN
ACUTE RENAL FAILURE
PERICARDITIS
NEUROPATHY
MENTAL STATUS CHANGE
SEIZURES
BLEEDING
TOXINS----ETHYLENE GLYCOL,
METHANOL
PROPHYLACTIC
~recent studies fail to document benefit
Indications for acute dialysis
AEIOU
Acidosis (metabolic)
Electrolytes (hyperkalemia)
Ingestion of drugs/Ischemia
Overload (fluid)
Uremia
MORTALITY ASSOCIATED WITH
SETTING OF ATN