Science Project

Recommendations (10)


http://www.chineseowl.idv.tw


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During our most recent weekly group meeting,
participants discussed how to more fully incorporate traditional
Chinese medicine in modern clinical practices.
Given its extensive use for many centuries, Chinese herbal
medicine has received increasing emphasis among clinical
researchers in Taiwan, as evidenced by the analysis of its efficacy
by several analytical methods. However, extracting
traditional Chinese medicine requires a large quantity of medicinal
components and cooking for extended periods, making it less
efficient to produce than Western medicine. (NOTE : Add 2-4
sentences that describe characteristics of the problem or statistics
that reflect its severity) For instance,
preparing traditional Chinese medicine for intake requires at least 2
hours in arrangement, making it an inefficient procedure.
The inability to adopt scientific methods to extract the
valid compounds of traditional Chinese medicine makes it
unfeasible for modern clinical practice owing to its inefficiency.
(:)
Therefore, we recommend developing an extraction
method for the valid compounds of traditional Chinese medicine through
animal-based clinical trials for eventual use in humans.
To do so, components of traditional Chinese medicine such as Chinese
rhubarb can be collected in a container and then extracted by
supercritical fluids. Following extraction, the traditional Chinese medicine
can then be analyzed quantitatively and qualitatively by LC-Mass. Next,
exactly what chemical elements are found in traditional Chinese medicine
can then be confirmed through analysis. Additionally, the major chemical
components can be adopted in animal or cell-based experiments.
As anticipated, the proposed extraction method can reduce nearly
half the time required by conventional approaches in extracting the valid
compounds of Chinese medicine, making it an economically viable
alternative. Moreover, the proposed method can
significantly reduce the time required to prepare Chinese medicine for
consumption, as well as ensure safe and modern applications for clinical
medicine. (NOTE : Add 2-4 more sentences that describe more
thoroughly how the proposed method contributes to a particular field or
sector)
(:)
At a recent meeting, members discussed the increasing
incidence of Alzheimers disease and current efforts to combat it.
As is well known, silver nanoparticles have an affinity with a proteins thiol and
amino group. Surface plasma resonance (SPR), a biosensor, can detect
proteins because silver nanoparticles have a coating on SPR, necessitating the
ability to use SPR sensitively and accurately SPR to detect proteins. For
instance, a protein containing amyloid -derived diffusible ligands (ADDLs)
causes Alzheimers disease. Although localized SPR (LSPR) is
more sensitive and accurate than the conventionally adopted SPR, LSPR has
many nanostructures, explaining why sensitivity and accuracy are of priority
concern. Moreover, the conventionally adopted SPR is more expensive than
LSPR. (NOTE : Add 2-4 sentences that describe characteristics of the
problem or statistics that reflect its severity) While the
sensitivity of SPR is 100pM, the LSPR must have a higher sensitivity and
accuracy, hopefully below 1pM. Developing a biosensor
without a LSPR would lead to a more expensive detector. Moreover, the
inability to increase sensitivity and accuracy of the biosensor makes it
impossible to detect the bio molecular structure in early stages, subsequently
creating greater problems such an increased societal burden in caring for
such patients.
(:)
Therefore, we recommend designing a sensitive and
accurate biosensor that can identify special proteins efficiently, as well as
detect certain diseases in their early stages. For instance, identifying the
protein ADDLs early can be used to diagnose Alzheimers disease in its
early stages so that therapeutic treatment can be administered.
To do so, nanoparticles can be developed in a glass chamber,
followed by design of a LSPR biosensor. The bio molecular structure can
then be detected using LSPR, enabling us to identify the disease.
As anticipated, the proposed analytical method for detecting bio
molecular structures can detect solution consistency below 1pM with a
high degree of accuracy. Moreover, the proposed LSPR
biosensor can provide a highly sensitive and accurate means of
detecting the bio molecular structure. The ability to identify the disease in
its early stages can lead to earlier treatment and recovery. For instance,
Alzheimers disease can be diagnosed early because LSPR can detect
ADDLs with a high degree of sensitivity, ultimately increasing the
survival rate of patients. (NOTE : Add 2 sentences that describe more
thoroughly how the proposed method contributes to a particular field or
sector)
Further details can be found at
http://www.chineseowl.idv.tw