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Group 2B: A Pulmonary Histoplasmosis Case
Group 2B: A Pulmonary Histoplasmosis Case
Group 2B: A Pulmonary Histoplasmosis Case
A pulmonary
Histoplasmosis case
CASE
A 33-year-old white female presents after admission to the general medical/surgical hospital ward with a chief complaint
of shortness of breath on exertion. She reports that she was seen for similar symptoms previously at her primary care
physician’s office six months ago. At that time, she was diagnosed with acute bronchitis and treated with bronchodilators,
empiric antibiotics, and a short course oral steroid taper. This management did not improve her symptoms, and she has
gradually worsened over six months. She reports a 20-pound intentional weight loss over the past year. She denies
camping, spelunking, or hunting activities. She denies any sick contacts. A brief review of systems is negative for fever,
night sweats, palpitations, chest pain, nausea, vomiting, diarrhea, constipation, abdominal pain, neural sensation
changes, muscular changes, and increased bruising or bleeding. She admits a cough, shortness of breath, and shortness
of breath on exertion.
Social History: Her tobacco use is 33 pack-years; however, she quit smoking shortly prior to the onset of symptoms, six
months ago. She denies alcohol and illicit drug use. She is married, in a monogamous relationship, and has three children
aged 15 months to 5 years. She is employed in a cookie bakery. She has two pet doves. She traveled to Mexico for a one-
week vacation, one year ago.
I.Demographic
Profile
I. Demographic Profile
Name: Patient X
Address: N/A
Age: 33 years old Birthdate: N/A
Gender: Female
Religion: Roman Catholic
Occupation: Employed in a cookie bakery
Marital Status: Married
Chief Complaints: Shortness of breath on exertion
Date of Admission: October 22, 2020
Room & Bed No: 406 - D
Attending / Admitting Physician: N/A
Admitting / Final Diagnosis: Based on the bronchoscopy findings, a diagnosis of
acute pulmonary histoplasmosis in an immunocompetent patient was made.
II. Past Health History
III. Present Health
History
II. Past Health History
The patient has a history of Hypertension and a past surgical history in which
Cholecystectomy is performed.
Interpretation & Analysis: Deviation from normal. The actions people take to
understand their health state, maintain an optimal state of health, prevent illness and
injury, and reach their maximum physical and mental potential. (Kozier and Erb’s,
Fundamentals of Nursing, 2012).
j. Activity and Exercise Pattern
She reports a 20-pound intentional weight loss over the past year. However, she stated
she has not done any outdoor activities such as camping, spelunking, or hunting
activities.
Interpretation & Analysis: Normal. The behaviors of people in activity and exercise are
paying attention to signs of illness. Exercising may also prevent affecting existing
disease and staying fit is staying health (Kozier and Erb’s, Fundamentals of Nursing,
2012).
VI. Physical
Assessment
A. General Survey
Assessment Method Normal Findings Actual Findings Analysis & Interpretation
Listen for Understandable, The client stops Deviation
quantity, quality, moderate pace, talking between Rapid or slow pace;
and organization exhibits thought mid-sentences overly loud or soft;
of speech. association. because of uses generalizations;
respiratory distress. lacks association,
difficulty in producing
words or sounds.
n.d. CBC Test WBCs - 5,000- CBC Test revealed Pancytopenia is a disorder where there are too
10,000/mm3 pancytopenia with a few red blood cells, white blood cells , and
RBCs - 4.2-5.4 platelet count of platelets in a person's body. Pancytopenia
Hgb - 12-16g/dl 74,000 per mm3; begins with a bone marrow problem. Blood cells
HCT - 37%-47% hemoglobin, 8.3 g are made in this spongy tissue inside the bones .
Plt count - 150,000- per and mild This bone marrow damage can result from
400,000/mm3 transaminase illnesses and exposure to some drugs and
elevation, AST 90 and chemicals.
ALT 112.
Reference: Healthline Medically reviewed by
Suzanne Falck, M.D., FACP — Written by
Stephanie Watson — Updated on September 18,
2018
Date Laboratory/ Normal Values Actual Results Clinical Interpretation & Analysis (with reference)
Done Diagnostic
Examination
n.d. Blood Normal- Negative for Normally, the blood has no bacteria or fungus in it.
Culture Test NEGATIVE (No bacterial growth and A blood culture is a test to identify germs that can
Bacteria found in gram staining cause an infection in a blood sample (such as
blood) bacteria or a fungus). Other severe diseases, such
Abnormal) as those affecting the lungs, liver, bowel,
gallbladder, or heart valves, most commonly occur
Abnormal- with a blood infection. When the immune system
POSITIVE is weak, a blood infection can also develop. Infants
(Bacteria were and older people, and diseases (such as cancer or
identified in AIDS) or medications (such as corticosteroids or
blood) chemotherapy) that affect how well the body can
combat infections (immunity) can cause this to
happen.
Reference: E. Gregory Thompson, MD - Internal
Medicine & Adam Husney, MD - Family Medicine
& Martin J. Gabica, MD - Family Medicine
University of Michigan Medicine, 2019
Date Laboratory/ Normal Values Actual Results Clinical Interpretation & Analysis (with reference)
Done Diagnostic
Examination
n.d. Cytology Negative for Cytology showed Histoplasmosis is a mycotic infection of the
Intraepithelial Histoplasma Histoplasma capsulatum dimorphic fungus.
Lesions or capsulatum Typically, the pathogens are contained within
Malignancy the cells (macrophages). In
(NILM)
immunocompetent people, this organism
mainly impacts the lungs and disseminated
forms are seen in immunocompromised
situations.
Reference: Role of fine-needle aspiration
cytology in diagnosis of disseminated
histoplasmosis in an immunocompetent
patient: A case report
J Cytol. 2016 Jul-Sep; 33(3): 163–165.
doi: 10.4103/0970-9371.177145
VIII. Drug Analysis
Drug Indication Contraindication Mechanism of Side Effect/ Nursing Responsibilities
Action Adverse effect
Lisinopril ➢HTN Contraindicated in Causes decreased CNS: dizziness, When using drug in acute
patients with production of headache, MI, give patient the
Therapeutic ➢Adjunctive hypertensive to angiotensin II and fatigue, appropriate and standard
class: treatment ACE inhibitors and suppression of paresthesia recommended treatment,
Antihypertens (with diuretics in those with a RAAS. CV: orthostatic such as thrombolytics,
ives and cardiac history of hypotension, aspirin, and beta blockers.
glycosides) angioedema hypotension,
Pharmacologi related to previous chest pain. -Monitor BP frequently. If
c class: ACE ➢Hemodyna treatment with EENT: nasal drug doesn’t adequately
inhibitors mically stable ACE inhibitor. congestion control BP, diuretics may be
patients GI:diarrhea, added.
Oral solution: within 24 -Use cautiously in nausea, dyspepsia
1mg/mL hours of acute patients with GU: impaired -Monitor WBC with
Tablets: MI to improve impaired renal renal function, differential counts before
2.5mg, 5mg, survival function; adjust impotence. therapy, every 2 weeks for
10mg, 20mg, dosage Metabolic: the first 3 months of
30mg, 40mg hyperkalemia therapy, and periodically
thereafter.
Respiratory:
dyspnea; dry,
persistent,tickling,
nonproductive
cough.
Drug Indication Contraindication Mechanism of Side Effect/ Nursing Responsibilities
Action Adverse effect
This problem classifies under the safety and security needs according to
Maslow’s Hierarchy, which focus on the knowledge promotion regarding
the predisposing factors and symptoms of Histoplasmosis infection. The
need for implementing interventions in accordance to the diagnosis imply
efficient measures for the client to adapt alteration on her behavioural
actions towards her health condition, and not limited on obtaining
knowledge.
Reference: Rankin, Stalling & London. Patient Education in Health and
Illness (2012)
4th: Risk for bleeding related to disseminated intravascular coagulopathy;
pancytopenia and impaired liver function; mild elevated transaminase.
This risk for bleeding classifies under the safety and security needs in
Maslow’s hierarchy. Sign and symptoms does not necessarily manifest any
excess bleeding yet, thus characterizing it as a prevention management to
ensure absence of complication. Related factors involved present bleeding
possibilities to occur due to increased vulnerability to excess bleeding
because of the lack of platelet count were affected by bone marrow
damaged from the infection, as well as produce impair liver function as an
integrated system during blood circulation.
Reference: Doenges, Moorhouse, & Murr. Nurse’s Pocket Guide: Diagnoses,
Prioritized Interventions, and Rationales. 14th edition
IX. Ecologic
Model
A. Hypothesis
Epidemiological Triad
In the pathogenesis of
Histoplasmosis
capsulatum infection, the
greater the harboring
factors present for the
suitable environmental
condition, the higher
possibility of fungi
contamination in the
environment to penetrate
the disease airborne
process to the susceptible
host
Predisposing Factors: A. Agent
a. Nutritive (Carbohydrates, Vitamins, Fat, Proteins, Mineral,
Water)
- Bird and Bat guano with Fatty acid composition of yeast cells
b. Chemical (Pollutants, Pesticides, Cosmetics)
- Fungal spores contaminant on the soil
c. Physical
- Dust from fungal spores formed in the environment
d. Infectious agent
- Fungi: Histoplasmosis
e. Mechanical
- N/A
f. Psychosocial
- N/A
Predisposing Factors: B. HOST
a. Genetic
- HLA (Human Leukocyte Antigen) gene B22
b. Age
- Middle aged adults and Older adults with a median age of
50-years-old
c. Sex/Gender
- Men (in Mexico)
d. Ethnic/Race
- Blu and Thai Dum groups (in Thailand)
e. Intercurrent infection
- HIV (human immunodeficiency virus)
- AIDS (acquired immunodeficiency syndrome)
- Pulmonary related-infection
Predisposing Factors: B. HOST
f. Human behaviour
- Environmental hygiene inside the pet cage and aviaries.
g. Religion
k. Social class membership
- N/A
- N/A
h. Family size
l. Resistance
- N/A
- N/A
i. Occupation
- Ornithologist (Studies birds), Cave tourist guide
- Game-cock handlers, Farmer
- Labor occupation that exert activities in mines
- Maintenance worker in the birds or bat area
- Food seller of Bat (predominant in the Southeast Asia)
j. Personality type
- N/A
Predisposing Factors: C.Environment
1. Physical
a. Geography:
- Mexico (Juxtlahuaca and Olinala, State of Guerrero)
- Central America (Ohio and Mississippi River valleys)
- South America ((Brazil, French Guiana, Perù and Venezuela)
- Africa (Congo, Tanzania-, and South Africa’s Guateng and
Limpopo provinces)
- Southeast Asia (Malaysia, Thailand, Indonesia, Philippines,
China)
b. Temperature/ humidity d. Weather /climate
- 37 degree Celsius - Humid Weather
c. Geology e. Air quality
- N/A - N/A
f. Noise
- N/A
Predisposing Factors: C.Environment
2. Biologic
a. Human population
density: (A large living space of birds
- United States of where they freely fly)
America : 3.4 cases per - Cave tourist spots
100,000 population - Poultry Farms
b. Fauna (animal life): c. Income – N/A
- Bird and bat guano d. social disruptions
c. Flora (plant life): - Preexisting endemic
- N/A recorded countries (In Mexico
3. Socio-economic & Central America)
a. urban overcrowding e. Availability of health
– N/A services– N/A
b.Workplaces contain the f. Culture
agent: - Thai culture
- Zoo park or Aviaries g. tensions & pressures
- N/A
Lever Model
V. Analysis
This risk for bleeding classifies under the safety and security needs in
Maslow’s hierarchy. Sign and symptoms does not necessarily manifest any
excess bleeding yet, thus characterizing it as a prevention management to
ensure absence of complication. Related factors involved present bleeding
possibilities to occur due to increased vulnerability to excess bleeding
because of the lack of platelet count were affected by bone marrow
damaged from the infection, as well as produce impair liver function as an
integrated system during blood circulation.
Reference: Doenges, Moorhouse, & Murr. Nurse’s Pocket Guide: Diagnoses,
Prioritized Interventions, and Rationales. 14th edition
VI. Conclusion and Recommendation
This risk for bleeding classifies under the safety and security needs in
Maslow’s hierarchy. Sign and symptoms does not necessarily manifest any
excess bleeding yet, thus characterizing it as a prevention management to
ensure absence of complication. Related factors involved present bleeding
possibilities to occur due to increased vulnerability to excess bleeding
because of the lack of platelet count were affected by bone marrow
damaged from the infection, as well as produce impair liver function as an
integrated system during blood circulation.
Reference: Doenges, Moorhouse, & Murr. Nurse’s Pocket Guide: Diagnoses,
Prioritized Interventions, and Rationales. 14th edition
Contribution to Nursing Practice
When spores produced by the Histoplasmosis mycelial form become airborne, they are inhaled and
deposited in alveoli. The spores germinate into the yeast form of this dimorphic fungus at normal
body temperature (37 ° C [98.6 ° F]) and are ingested by pulmonary macrophages. The yeasts become
parasitic, multiply within these cells, and move to the lymph nodes of the hilar and mediastinal,
where they gain access to the blood circulation that spreads them to different organs. The organism is
consumed and sequestered by macrophages through the reticuloendothelial system
Overview of Disease
20% of healthy
Endemic individuals can be affected Life-threatening
illness
• Prayer and meditation should be done more than once daily to maintain
good spirituality, considering the client is Roman Catholic.