Related Article

• Chronic diseases are the major cause of death and disability worldwide
- Statistics shows there are 346 million cases of DM and 350 million cases of
MDD worldwide
• According to WHO there is a High prevalence of MDD in DM patients
• - Patients suffering with DM had double the risk of MDD
• - 1 out of 3 DM patients have MDD
• - diabetic woman have higher risk of MDD
• - no difference in in the prevalence of DM1 and DM2
• - 40 % of DM patients develops MDD after a period of 2 years
• - prevalence of MDD varies systematically on the instrument and sample used
• Treatment
• - MDD is related to increased hyperglycemia thus treatment of MDD may
lead to good glycemic control
• Studies about bidirectional relationship of DM and MDD concluded that
MDD was associated with 60% increase in the occurrence of DM
• Longitudinal studies provides strong epidemiological evidence that MDD
increases the risk of DM2
• - MDD is associated with poor health behaviors (smoking, lack of physical activity and
high caloric intake)
• Cosgrove et al. concluded that MDD causes DM2 and not the opposite
• - 13 meta analysis shows high incident rate of DM in individuals who already have
MDD
• Treatment
• Imipramine reversed the depressive behavior seen in diabetic animals and increases
level of BDNF
• Be cautious when using antidepressants they can also induce impairment in insulin
production and signaling
• Conclusion
It was found out that individuals with MDD are more likely to develop DM
than those without MDD.
• - MDD is associated with physiological abnormalities
• Which can induce insulin resistance and contribute to increase RISK of DM
• - MDD is associated with psychological stress
• - leading to release of counter regulatory hormone
• Which counteracts the hypoglycemic action of insulin by increasing level of blood glucose