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Disorders of Renal Function

Acute Renal Injury


Chronic Kidney Disease

Ms. Cres P. Quinzon RN MAN


Oman College of Health Sciences Dhofar
Pathophysiology
2020-2021
Objectives
Discuss the etiology and pathogenesis of
Acute Renal Injury
State the most common cause of
Chronic Renal Injury

Discuss the mechanism of


Chronic Kidney Disease
Self-Learning Activity:
Urinary tract obstruction
Urinary stasis
Neurogenic bladder
Urinary incontinence
ACUTE Acute renal injury or also termed
acute kidney injury (AKI)
RENAL represents a rapid decline in
INJURY kidney function sufficient to
increase blood levels of
nitrogenous wastes and impair
fluid and electrolyte balance
CAUSES OF
ACUTE RENAL
FAILURE
CAUSES OF ACUTE RENAL
FAILURE
PRE-RENAL INTRA RENAL POST RENAL
most common form of ARF Caused
results from obstruction of urine
by marked decrease in renal blood
outflow from the kidney
flow. Or Acute Kidney Injury results from
The obstruction can occur,in the
It is reversible if the cause of the conditions that cause damage to
ureter (calculi), bladder (tumors or
decreased renal blood flow can be structures within the kidney
neurogenic bladder), or urethra
identified and corrected before
(prostatic hyperplasia)
kidney damage occurs.
CAUSES: Hypovolemia
(Hemorrhage, dehydration, CAUSES: Acute tubular necosis
excessive loss of GI fluids; burn) Prolonged renal ischemia
Decrease vascular filling Exposure to nephrotoxic drugs Bilateral ureteral obstruction
(anaphylactic and septic shock) Acute Renal Disease Bladder outlet obstruction
Heart Failure and Cardiogenic Shock ( glomerulonephritis and
Decreased Renal perfusion due to pyelonephritis)
sepsis and drugs
CAUSES OF
ACUTE RENAL
FAILURE
Pathogenesis of Acute Kidney
Injury
(Intrarenal Renal Injury)

Reduced GFR
Intrarenal
Vasoconstriction (Glomerular Tubular injury
causes
Filtration Rate)
CHRONIC KIDNEY DISEASE

kidney damage or a GFR less


than 60 mL/min/1.73 m2 for 3
months or longer
MECHANISM OF CHRONIC KIDNEY DISEASE

CKD represents a loss of functioning


kidney nephrons with progressive
deterioration of glomerular filtration,
tubular re-absorptive capacity, and
endocrine functions of the kidneys
MECHANISM OF CHRONIC KIDNEY DISEASE
THANKS!
Does anyone
have any
questions?

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