Scale up Calculations

Hydrogenation reactions
• Lab data • Plant data
- Mass transfer coefficient's - Mixing data
- Solubility data - Vessel geometry
- Mixing data
- Vessel geometry

• Predictions
- RPM,
- Pressure,
- Duration of reaction,
- Batch size
 MASS TRANSFER COEFFICIENT
•  Volumetric mass transfer coefficient kla (1/sec)
• Gas absorption rate =N (mol/sec)
• Initial gas absorption rate= No (mol/sec)
Kla worksheet
• Time=t (sec)

Formula :-

Plot graph between ln(N/No) and time , then slope of linear graph is kla.
Solubility data
••The
  gas solubility ( ) can be determined by monitoring the initial and final pressures:
 

Where, solubility of gas

 VG, Gas volume
 VL, Liquid volume
 R , Gas constant (8.31 kJ/(kmol K))
 ,Gas absorption coefficient [kmol/(m³ kPa)]
 H ,Henry constant [(m³ kPa)/kmol]
 Pm, Desired pressure, bar
 P0 , Initial Pressure, bar
 P∞ , Final Pressure, bar
 Mixing data
IMPELLER P0
P = Po ρ (N^3) (D^5) POWER PER UNIT MASS (ɛ)= xx (w/kg)
ANCHOR 0.4
Pitched Blade Turbine
1.8
(PBT)
Rotary Disk Turbine (RDT) 5
Where
Retreat Curve Impeller
(RCI)
0.6 P=power (watts)
Po=power number for selected agitator
ρ = density of liquid (kg/m3 )
N=RPS (Sec-1)
D=Diameter of agitator (m)

Mixing study
Lab scale Vessel geometry
Syrris reactor Agitators
• Reactor volume :2 L • Anchor
• Inner diameter of vessel:130mm
• PBT
• Retreat curve
• Outer diameter of vessel:140mm • Propeller
• Fill height of vessel:159mm

Agitator Shaft Diameter Diameter Width Thickness

Anchor 8mm 76 10 10
PBT -1 8 50 21 4
PBT-2 8 40 21 4
Retreat curve 8 74 18 3.5
Propeller 8 74 20 5
Chemical reactions (Liq-Liq, Solid-Liq, Liq-
Gas, Solid-Liq-Gas systems)
• Plant data
• Lab data
- Vessel geometry
- Mixing data
- Vessel geometry

• Predictions
- RPM,
- Duration of reaction,
- Batch size
Plant Operating conditions (Range)

SSR-105
• Temperature • Reactor volume:600 L
• Agitator: PBT+PBT
• Pressure • Minimum stirrable volume:85 L
• Minimum sensing volume:-110 L
• Volume • RPM:60-120
• Temperature:-20°C to 140°C
• Impeller type • Pressure: 1 to 1.5 kg/cm2
• MOC • MOC: stainless steel

• Batch size