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Presentasi PIT RAN-edited
Presentasi PIT RAN-edited
1
BACKGROUND
MATERNAL FACTORS
? ?
IGF - 1
…background
Human milk is uniquely suited to the human infant, both in its nutritional
composition and in the non-nutritive bioactive factors that promote
survival and healthy development.
Oftedal OT. The evolution of milk secretion and its ancient origins.
Animal : an international journal of animal bioscience. 2012; 6(3):355–368
• Cells
• Immunoglobulins
• Cytokines
• Chemokines
• Growth Factors
• Hormones
• Anti microbials
• Metabolic hormones
• Oligosacharides and glycans
• Mucin
• Probiotics
…background
INSULIN-LIKE GROWTH FACTORS
IGF-I and IGF-II, as well as IGF binding proteins and IGF-specific proteases,
are found in human milk.
(Burrin, 1997; Blum & Baumrucker, 2002; Phillip et al., 2002)
Levels are highest in colostrum, and steadily decline over the course of
lactation
(Posser, 1996; Milsom et al., 2008)
There are no significant differences between preterm and term milk, with
the exception of IGF binding protein-2, which is higher in preterm milk
(Blum & Baumrucker, 2002; Elmlinger et al., 2007)
…background
Maternal serum IGF-1 was the main source of IGF-1 in breast milk.
(Tavakkol et al., 1988; Posser et al., 1987)
Maternal body mass index was measured and neonatal birth weight was obtained soon after delivery
IGF-1 levels of breast milk was measured at third day after by ELISA method
GH
IGFPB
DISCUSSION
Levels of IGF1, IGF2 and
IGFBP3 correlate best with
spontaneous GH secretion
Undernutrition of either
protein or energy intake
(Bajpal and Menon, 2006 )
substantially lowers IGF-1
GH and nutrition are the levels
Jahnson et al. Maternal hormones linking major factors that regulate
maternal body mass index and dietary intake (Thissen et al., 1994)
to birth weight. hepatic IGF-I expression, as
Am J Clin Nutr. 2008:87:1743-9 well as in other organs
Overconsumption may
(Daughaday & Rotwein, 1989; Clemmons, 1991 )
increase IGF-1, but excess
calories are not nearly as
strong a stimulus as
nutritional restriction.