PHARMACOLOGY RANITIDINE

DRUGS OF GASTRITIS
By
Dea Vionita (1808010102) 5B
What is gastritis?
● Gastritis is a disease of the stomach that occurs due to inflammation
of the stomach wall. On the stomach wall or lining of the gastric
mucosa there are glands that produce stomach acid and a digestive
enzyme called pepsin. To protect the mucosal lining of the stomach
from damage caused by stomach acid, the walls of the stomach are
covered with thick mucus. If the mucus is damaged, the stomach wall
is prone to inflammation.
Symptoms of gastritis can be different for
each patient. However, this condition may not
always cause symptoms. Some examples of
gastritis symptoms are:
• Pain that feels hot and sore in the stomach.
• Bloated.
• Hiccup.
• Nausea.
• Loss of appetite.
• Feel full quickly when eating.
• Defecate with black stool.
• Vomiting blood.
• gag
Causes of Gastritis
-          Helicobacter pylory bacterial
infection
-          Irregular diet and lifestyle
-          Caused by spicy, sour foods, soft
drinks, coffee and tea
-          Smoking habit
-          Continuous use of NSID drugs
-          Psychic stress can be one of the
factors of recurrence.
What is ranitidine? And how the pharmacology
● Ranitidine is a reversible competitive antagonist of histamine
receptors on parietal cells of the gastric mucosa which functions to
secrete gastric acid. Ranitidine suppresses gastric acid secretion by 2
mechanisms:
● Histamine produced by gastric ECL cells is inhibited because
ranitidine occupies H2 receptors which function to stimulate gastric
acid secretion
● .  Other substances (gastrin and acetylcholine) that cause gastric acid
secretion, are less effective on parietal cells when H2 receptors are
inhibited.
● Ranitidine HCI is a histamine H2 receptor antagonist which inhibits
histamine action competitively on H2 receptors and reduces gastric acid
secretion. In IM / IV administration, the serum level needed to inhibit 50% of
stimulation of gastric acid secretion is 36-94 mg / mL. These levels last for
6-8 hours. In oral administration Ranitidine HCI is absorbed 50% after oral
administration. Peak plasma concentrations are achieved 2-3 hours after the
150 mg dose. Absorption is not significantly affected by food and antacids.
Half-life 214-3 hours on oral administration. Ranitidine HCI is excreted in
the urine.
THANKYOU