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    DNA Repair Mechanisms

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    Maria Chiorescu
    The document outlines various DNA repair mechanisms in cells including nucleotide excision repair (NER), base excision repair (BER), mismatch repair (MMR), and double-strand break repair (DSB). It shows the proteins and pathways involved in detecting and repairing damage from UV light, ionizing radiation, and other sources. The repair mechanisms help maintain genome integrity and prevent DNA damage from causing cell proliferation issues or initiating apoptosis.

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    DNA Repair Mechanisms

    Uploaded by

    Maria Chiorescu
    38 views1 page
    The document outlines various DNA repair mechanisms in cells including nucleotide excision repair (NER), base excision repair (BER), mismatch repair (MMR), and double-strand break repair (DSB). It shows the proteins and pathways involved in detecting and repairing damage from UV light, ionizing radiation, and other sources. The repair mechanisms help maintain genome integrity and prevent DNA damage from causing cell proliferation issues or initiating apoptosis.

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    The document outlines various DNA repair mechanisms in cells including nucleotide excision repair (NER), base excision repair (BER), mismatch repair (MMR), and double-strand break repair (DSB). It shows the proteins and pathways involved in detecting and repairing damage from UV light, ionizing radiation, and other sources. The repair mechanisms help maintain genome integrity and prevent DNA damage from causing cell proliferation issues or initiating apoptosis.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as ppt, pdf, or txt
    38 views1 page

    DNA Repair Mechanisms

    Uploaded by

    Maria Chiorescu
    The document outlines various DNA repair mechanisms in cells including nucleotide excision repair (NER), base excision repair (BER), mismatch repair (MMR), and double-strand break repair (DSB). It shows the proteins and pathways involved in detecting and repairing damage from UV light, ionizing radiation, and other sources. The repair mechanisms help maintain genome integrity and prevent DNA damage from causing cell proliferation issues or initiating apoptosis.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as ppt, pdf, or txt
    of 1

    DNA Repair Mechanisms

    Rad22
    UV Light
    Rad21
    3’
    Rad18
    Ku

    5’
    XPC Rad23
    23B
    XPA hHR T
    Rad4
    XPA

    NER Rad16

    T
    Rad2
    Rad7
    CSB TFIIH
    Repair Rad50
    CSA
    l MRE11
    PNK po NBS1
    p21 Transcription
    XAB2
    Coupled Excision DNA D
    amag
    Check e Rad24
    XPG RFP point
    ATRIP
    Cell Rad17
    pol WRN
    Proliferation
    PCNA PCNA
    Ku
    Rad9 DNA Damage DSB Repair DNA-PK NO
    Hus1 P
    Rad1 Checkpoint Cross-link
    Apoptosis RPA
    Ionizing Repair FANCs
    5
    D D4 Radiation Pol-
    GA IR Dama
    ge Repa
    ir
    ir
    JNK SNM1 RFC
    p53
    ERCC1
    hOGG1
    BRCA1
    Estrogen XPF XRCC1 PARP
    BER PNK
    TAX PCNA
    RPA Lig3 Pol-
    IGF1R
    Transcription p21
    XPG
    FEN1
    p53 P G1
    C-Abl Vpr
    Rad52
    p21 Rad51 EXO1
    MSH2
    PMS2
    Ionizing MSH3/6 S
    MLH1
    G1 MDM2 Radiation UNG
    Rad55 Lig1
    Pol-/
    pRb T SMUG1
    MMR PCNA
    C ATR U
    E MBD4
    CpG
    L S Chk2
    L TpG
    P ATM Deacylation & Demethylation
    C Chk1
    G of Guanine
    Y BRCA2 TREX2
    C G2
    L TREX1
    E Sister Chromatid MGMT
    EXO1
    Exchange Abasic
    5’ hNTH
    HAP1
    Site
    RCC1
    Mitosis 3’

    Nucleus

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